Positive Kinase

biogrid+hippie (Leiden)

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source	term_id	annotation	description	intersection_size	p_value
REAC	REAC:R-HSA-9755779	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	7	3.947320e-13
REAC	REAC:R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	8.534149e-13
REAC	REAC:R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	3.186566e-12
REAC	REAC:R-HSA-111447	Activation of BAD and translocation to mitochondria	Activation of BAD and translocation to mitochondria	7	3.186566e-12
REAC	REAC:R-HSA-69473	G2/M DNA damage checkpoint	G2/M DNA damage checkpoint	10	5.086022e-11
REAC	REAC:R-HSA-69620	Cell Cycle Checkpoints	Cell Cycle Checkpoints	13	4.438025e-10
REAC	REAC:R-HSA-114452	Activation of BH3-only proteins	Activation of BH3-only proteins	7	9.760895e-10
REAC	REAC:R-HSA-69481	G2/M Checkpoints	G2/M Checkpoints	10	1.716942e-08
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	10	2.891240e-08
REAC	REAC:R-HSA-9614399	Regulation of localization of FOXO transcription factors	Regulation of localization of FOXO transcription factors	5	5.853243e-08
REAC	REAC:R-HSA-109606	Intrinsic Pathway for Apoptosis	Intrinsic Pathway for Apoptosis	7	8.063479e-08
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	10	1.500791e-07
REAC	REAC:R-HSA-1643685	Disease	Disease	22	1.912570e-07
REAC	REAC:R-HSA-199991	Membrane Trafficking	Membrane Trafficking	14	5.510306e-07
REAC	REAC:R-HSA-195258	RHO GTPase Effectors	RHO GTPase Effectors	11	5.658852e-07
REAC	REAC:R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	Translocation of SLC2A4 (GLUT4) to the plasma membrane	7	6.451821e-07
REAC	REAC:R-HSA-1640170	Cell Cycle	Cell Cycle	14	1.615141e-06
REAC	REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	TP53 Regulates Metabolic Genes	7	1.933037e-06
REAC	REAC:R-HSA-194315	Signaling by Rho GTPases	Signaling by Rho GTPases	14	2.436720e-06
REAC	REAC:R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	14	3.199150e-06
REAC	REAC:R-HSA-5653656	Vesicle-mediated transport	Vesicle-mediated transport	14	3.375583e-06
REAC	REAC:R-HSA-5625740	RHO GTPases activate PKNs	RHO GTPases activate PKNs	7	3.965348e-06
REAC	REAC:R-HSA-9692914	SARS-CoV-1-host interactions	SARS-CoV-1-host interactions	7	4.605274e-06
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	16	7.567073e-06
REAC	REAC:R-HSA-3371511	HSF1 activation	HSF1 activation	4	1.338588e-05
REAC	REAC:R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response	6	1.728155e-05
REAC	REAC:R-HSA-3700989	Transcriptional Regulation by TP53	Transcriptional Regulation by TP53	10	2.847550e-05
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	14	3.955607e-05
REAC	REAC:R-HSA-9678108	SARS-CoV-1 Infection	SARS-CoV-1 Infection	7	6.791052e-05
REAC	REAC:R-HSA-3371556	Cellular response to heat stress	Cellular response to heat stress	6	8.370023e-05
REAC	REAC:R-HSA-9726842	Gain-of-function MRAS complexes activate RAF signaling	Gain-of-function MRAS complexes activate RAF signaling	3	5.411217e-04
REAC	REAC:R-HSA-9726840	SHOC2 M1731 mutant abolishes MRAS complex function	SHOC2 M1731 mutant abolishes MRAS complex function	3	5.411217e-04
REAC	REAC:R-HSA-9660537	Signaling by MRAS-complex mutants	Signaling by MRAS-complex mutants	3	5.411217e-04
REAC	REAC:R-HSA-9614085	FOXO-mediated transcription	FOXO-mediated transcription	5	5.864765e-04
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	21	6.186834e-04
REAC	REAC:R-HSA-9705683	SARS-CoV-2-host interactions	SARS-CoV-2-host interactions	7	6.855511e-04
REAC	REAC:R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	Caspase-mediated cleavage of cytoskeletal proteins	3	2.107929e-03
REAC	REAC:R-HSA-9828806	Maturation of hRSV A proteins	Maturation of hRSV A proteins	3	2.734519e-03
REAC	REAC:R-HSA-69166	Removal of the Flap Intermediate	Removal of the Flap Intermediate	3	3.472947e-03
REAC	REAC:R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	3	3.472947e-03
REAC	REAC:R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	3	3.472947e-03
REAC	REAC:R-HSA-69183	Processive synthesis on the lagging strand	Processive synthesis on the lagging strand	3	4.332016e-03
REAC	REAC:R-HSA-392517	Rap1 signalling	Rap1 signalling	3	4.332016e-03
REAC	REAC:R-HSA-5358508	Mismatch Repair	Mismatch Repair	3	4.332016e-03
REAC	REAC:R-HSA-9820965	Respiratory syncytial virus (RSV) genome replication, transcription and translation	Respiratory syncytial virus (RSV) genome replication, transcription and translation	3	5.320453e-03
REAC	REAC:R-HSA-110312	Translesion synthesis by REV1	Translesion synthesis by REV1	3	5.320453e-03
REAC	REAC:R-HSA-5655862	Translesion synthesis by POLK	Translesion synthesis by POLK	3	6.446908e-03
REAC	REAC:R-HSA-5656121	Translesion synthesis by POLI	Translesion synthesis by POLI	3	6.446908e-03
REAC	REAC:R-HSA-174437	Removal of the Flap Intermediate from the C-strand	Removal of the Flap Intermediate from the C-strand	3	6.446908e-03
REAC	REAC:R-HSA-9694516	SARS-CoV-2 Infection	SARS-CoV-2 Infection	7	9.080904e-03
REAC	REAC:R-HSA-174414	Processive synthesis on the C-strand of the telomere	Processive synthesis on the C-strand of the telomere	3	9.148093e-03
REAC	REAC:R-HSA-110320	Translesion Synthesis by POLH	Translesion Synthesis by POLH	3	9.148093e-03
REAC	REAC:R-HSA-2028269	Signaling by Hippo	Signaling by Hippo	3	9.148093e-03
REAC	REAC:R-HSA-69186	Lagging Strand Synthesis	Lagging Strand Synthesis	3	1.073974e-02
REAC	REAC:R-HSA-69278	Cell Cycle, Mitotic	Cell Cycle, Mitotic	9	1.110385e-02
REAC	REAC:R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	PCNA-Dependent Long Patch Base Excision Repair	3	1.250325e-02
REAC	REAC:R-HSA-212436	Generic Transcription Pathway	Generic Transcription Pathway	13	1.452250e-02
REAC	REAC:R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	3	2.144020e-02
REAC	REAC:R-HSA-2173788	Downregulation of TGF-beta receptor signaling	Downregulation of TGF-beta receptor signaling	3	2.144020e-02
REAC	REAC:R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	Gap-filling DNA repair synthesis and ligation in GG-NER	3	2.144020e-02
REAC	REAC:R-HSA-9679506	SARS-CoV Infections	SARS-CoV Infections	8	2.175432e-02
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	10	3.561181e-02
REAC	REAC:R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	Recognition of DNA damage by PCNA-containing replication complex	3	3.744902e-02
REAC	REAC:R-HSA-73857	RNA Polymerase II Transcription	RNA Polymerase II Transcription	13	3.887314e-02
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	10	4.121193e-02
REAC	REAC:R-HSA-5656169	Termination of translesion DNA synthesis	Termination of translesion DNA synthesis	3	4.555772e-02
REAC	REAC:R-HSA-69190	DNA strand elongation	DNA strand elongation	3	4.555772e-02
REAC	REAC:R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	Regulation of mRNA stability by proteins that bind AU-rich elements	4	4.886113e-02

source	term_id	annotation	description	intersection_size	p_value
WP	WP:WP5376	17p13 3 YWHAE copy number variation	17p13 3 YWHAE copy number variation	7	5.650915e-11
WP	WP:WP179	Cell cycle	Cell cycle	8	8.907969e-07
WP	WP:WP2446	Retinoblastoma gene in cancer	Retinoblastoma gene in cancer	6	8.332274e-05
WP	WP:WP536	Calcium regulation in cardiac cells	Calcium regulation in cardiac cells	7	1.046570e-04
WP	WP:WP289	Myometrial relaxation and contraction pathways	Myometrial relaxation and contraction pathways	7	1.250795e-04
WP	WP:WP3875	ATR signaling	ATR signaling	3	9.693378e-04
WP	WP:WP2814	Mammary gland development puberty stage 2 of 4	Mammary gland development puberty stage 2 of 4	3	1.672134e-03
WP	WP:WP706	Sudden infant death syndrome SIDS susceptibility pathways	Sudden infant death syndrome SIDS susceptibility pathways	6	2.461037e-03
WP	WP:WP5265	Neurogenesis regulation in the olfactory epithelium	Neurogenesis regulation in the olfactory epithelium	4	6.641350e-03
WP	WP:WP5401	7q11 23 distal copy number variation	7q11 23 distal copy number variation	3	8.811339e-03
WP	WP:WP531	DNA mismatch repair	DNA mismatch repair	3	1.010875e-02
WP	WP:WP45	G1 to S cell cycle control	G1 to S cell cycle control	4	1.049948e-02
WP	WP:WP2037	Prolactin signaling	Prolactin signaling	4	1.854992e-02
WP	WP:WP4666	Hepatitis B infection	Hepatitis B infection	5	2.597503e-02

source	term_id	annotation	description	intersection_size	p_value
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	30	9.834863e-10
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	20	4.919385e-09
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	20	6.367622e-09
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	20	6.422183e-09
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	20	6.422183e-09
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	11	2.000250e-08
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	11	2.560413e-08
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	14	3.173332e-08
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	23	1.856164e-06
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	20	1.480792e-05
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	17	2.584069e-05
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	21	1.875849e-04
GO:CC	GO:0005662	DNA replication factor A complex	"A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]	3	2.979053e-04
GO:CC	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	5	3.278995e-04
GO:CC	GO:0042470	melanosome	"A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]	5	3.278995e-04
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	35	3.735950e-04
GO:CC	GO:0043601	nuclear replisome	"A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]	3	1.587084e-03
GO:CC	GO:0030894	replisome	"A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]	3	2.080944e-03
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	14	7.316147e-03
GO:CC	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	38	8.349966e-03
GO:CC	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	37	9.284369e-03
GO:CC	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	3	1.074142e-02
GO:CC	GO:0072357	PTW/PP1 phosphatase complex	"A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061]	2	1.354378e-02
GO:CC	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]	10	1.567628e-02
GO:CC	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	7	2.008820e-02
GO:CC	GO:0097447	dendritic tree	"The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]	7	2.048728e-02
GO:CC	GO:0043232	intracellular membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	23	2.214979e-02
GO:CC	GO:0043228	membraneless organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	23	2.220649e-02
GO:CC	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	10	2.546778e-02
GO:CC	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	7	2.556197e-02
GO:CC	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	8	2.570008e-02
GO:CC	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	4	4.666984e-02
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	13	4.681024e-02
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	13	4.793005e-02

source	term_id	annotation	description	intersection_size	p_value
KEGG	KEGG:04390	Hippo signaling pathway	Hippo signaling pathway	10	2.193707e-09
KEGG	KEGG:04114	Oocyte meiosis	Oocyte meiosis	8	3.936306e-07
KEGG	KEGG:04110	Cell cycle	Cell cycle	8	1.644688e-06
KEGG	KEGG:05160	Hepatitis C	Hepatitis C	8	1.728728e-06
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	9	7.810368e-05
KEGG	KEGG:05203	Viral carcinogenesis	Viral carcinogenesis	6	2.519050e-03
KEGG	KEGG:03430	Mismatch repair	Mismatch repair	3	3.435583e-03
KEGG	KEGG:05161	Hepatitis B	Hepatitis B	5	1.034963e-02
KEGG	KEGG:03030	DNA replication	DNA replication	3	1.345867e-02
KEGG	KEGG:03440	Homologous recombination	Homologous recombination	3	1.987305e-02
KEGG	KEGG:05205	Proteoglycans in cancer	Proteoglycans in cancer	5	3.085550e-02
KEGG	KEGG:03460	Fanconi anemia pathway	Fanconi anemia pathway	3	4.493288e-02

source	term_id	annotation	description	intersection_size	p_value
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	14	2.300254e-09
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	21	4.257171e-09
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	10	1.714540e-07
GO:MF	GO:0050815	phosphoserine residue binding	"Binding to a phosphorylated serine residue within a protein." [GOC:ai]	4	8.931166e-07
GO:MF	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	7	2.386456e-05
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	10	2.474311e-05
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	11	5.990590e-05
GO:MF	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	6	1.130121e-04
GO:MF	GO:0140311	protein sequestering activity	"Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:1493333]	4	1.134598e-04
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	10	2.279631e-04
GO:MF	GO:0140313	molecular sequestering activity	"Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:13130076]	4	1.005824e-03
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	15	1.643780e-03
GO:MF	GO:0045309	protein phosphorylated amino acid binding	"Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators]	4	1.812254e-03
GO:MF	GO:0008426	protein kinase C inhibitor activity	"Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai]	2	4.178297e-03
GO:MF	GO:0008157	protein phosphatase 1 binding	"Binding to a protein phosphatase 1." [GOC:jl]	3	5.542882e-03
GO:MF	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	38	6.156026e-03
GO:MF	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	4	1.110704e-02
GO:MF	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	16	2.612525e-02
GO:MF	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	4	3.213735e-02

source	term_id	annotation	description	intersection_size	p_value
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	26	8.081246e-09
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	22	1.644758e-07
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	22	1.791592e-07
GO:BP	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	20	1.131925e-06
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	22	3.284402e-06
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	22	1.376365e-05
GO:BP	GO:0007049	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]	16	1.418587e-05
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	22	1.438025e-05
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	13	1.918861e-05
GO:BP	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	22	2.568795e-05
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	17	2.755405e-05
GO:BP	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	20	3.666849e-05
GO:BP	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	13	4.430123e-05
GO:BP	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]	12	4.817195e-05
GO:BP	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	20	5.453538e-05
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	14	8.822729e-05
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	26	1.143790e-04
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	16	2.346255e-04
GO:BP	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	29	3.874029e-04
GO:BP	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	15	4.125919e-04
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	11	5.839153e-04
GO:BP	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	30	8.756201e-04
GO:BP	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	18	9.013590e-04
GO:BP	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	15	9.584611e-04
GO:BP	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	21	1.047136e-03
GO:BP	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	17	1.228139e-03
GO:BP	GO:0071840	cellular component organization or biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]	30	1.651283e-03
GO:BP	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	14	1.870288e-03
GO:BP	GO:0021762	substantia nigra development	"The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420]	4	2.390077e-03
GO:BP	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	9	3.079351e-03
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	25	3.127199e-03
GO:BP	GO:0046822	regulation of nucleocytoplasmic transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]	5	3.177885e-03
GO:BP	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	14	3.257197e-03
GO:BP	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	26	3.828102e-03
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	22	3.950009e-03
GO:BP	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	26	3.990828e-03
GO:BP	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	20	4.459620e-03
GO:BP	GO:0141124	intracellular signaling cassette	"An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg]	14	4.666903e-03
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	14	5.442192e-03
GO:BP	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	11	5.690481e-03
GO:BP	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	21	6.335869e-03
GO:BP	GO:0048869	cellular developmental process	"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]	21	6.359914e-03
GO:BP	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	9	6.431901e-03
GO:BP	GO:0021782	glial cell development	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	5	6.460850e-03
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	20	6.806873e-03
GO:BP	GO:1903047	mitotic cell cycle process	"A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]	9	8.486010e-03
GO:BP	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	27	8.918490e-03
GO:BP	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	30	9.278131e-03
GO:BP	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	8	1.089718e-02
GO:BP	GO:0032386	regulation of intracellular transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	6	1.189972e-02
GO:BP	GO:0048857	neural nucleus development	"The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021]	4	1.192613e-02
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	12	1.195178e-02
GO:BP	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	17	1.320890e-02
GO:BP	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	24	1.467438e-02
GO:BP	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	12	1.493636e-02
GO:BP	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	12	1.564805e-02
GO:BP	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	25	1.626042e-02
GO:BP	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	11	1.664974e-02
GO:BP	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	15	1.720864e-02
GO:BP	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	5	1.729719e-02
GO:BP	GO:0031399	regulation of protein modification process	"Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	10	1.881711e-02
GO:BP	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	23	1.953168e-02
GO:BP	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	14	2.300450e-02
GO:BP	GO:0008088	axo-dendritic transport	"The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194]	4	2.350357e-02
GO:BP	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	16	2.453719e-02
GO:BP	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	10	2.957026e-02
GO:BP	GO:1903077	negative regulation of protein localization to plasma membrane	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]	3	3.340289e-02
GO:BP	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	16	3.427653e-02
GO:BP	GO:0032200	telomere organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah]	5	3.608909e-02
GO:BP	GO:0030901	midbrain development	"The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177]	4	3.686429e-02
GO:BP	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	23	3.693520e-02
GO:BP	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	22	3.840755e-02
GO:BP	GO:1904376	negative regulation of protein localization to cell periphery	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]	3	4.070575e-02
GO:BP	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	3	4.070575e-02
GO:BP	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	23	4.780762e-02
GO:BP	GO:0023057	negative regulation of signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	11	4.856745e-02
GO:BP	GO:0043412	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	16	4.876397e-02
GO:BP	GO:0010648	negative regulation of cell communication	"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	11	4.888178e-02
GO:BP	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	9	4.900033e-02

source	term_id	annotation	description	intersection_size	p_value
CORUM	CORUM:5199	Kinase maturation complex 1	Kinase maturation complex 1	6	1.712788e-07
CORUM	CORUM:5229	RPA complex	RPA complex	2	1.663663e-02
CORUM	CORUM:5919	BRAF-RAF1-14-3-3 complex	BRAF-RAF1-14-3-3 complex	2	1.663663e-02
CORUM	CORUM:7269	p532-Clathrin-HSP70 complex	p532-Clathrin-HSP70 complex	2	4.969340e-02
CORUM	CORUM:5873	RAF1-MAP2K1-YWHAE complex	RAF1-MAP2K1-YWHAE complex	2	4.969340e-02

source	term_id	annotation	description	intersection_size	p_value
MIRNA	MIRNA:hsa-mir-16-5p	hsa-mir-16-5p	hsa-mir-16-5p	16	0.000017
MIRNA	MIRNA:hsa-mir-324-3p	hsa-mir-324-3p	hsa-mir-324-3p	15	0.000254
MIRNA	MIRNA:hsa-mir-615-3p	hsa-mir-615-3p	hsa-mir-615-3p	12	0.000269
MIRNA	MIRNA:hsa-mir-455-3p	hsa-mir-455-3p	hsa-mir-455-3p	13	0.001990
MIRNA	MIRNA:hsa-mir-30a-3p	hsa-mir-30a-3p	hsa-mir-30a-3p	6	0.002226
MIRNA	MIRNA:hsa-mir-302a-5p	hsa-mir-302a-5p	hsa-mir-302a-5p	5	0.002586
MIRNA	MIRNA:hsa-mir-4790-3p	hsa-mir-4790-3p	hsa-mir-4790-3p	10	0.003273
MIRNA	MIRNA:hsa-mir-4760-3p	hsa-mir-4760-3p	hsa-mir-4760-3p	12	0.008778
MIRNA	MIRNA:hsa-mir-1913	hsa-mir-1913	hsa-mir-1913	12	0.015425
MIRNA	MIRNA:hsa-mir-30e-3p	hsa-mir-30e-3p	hsa-mir-30e-3p	5	0.015983
MIRNA	MIRNA:hsa-let-7e-5p	hsa-let-7e-5p	hsa-let-7e-5p	8	0.016373
MIRNA	MIRNA:hsa-mir-4506	hsa-mir-4506	hsa-mir-4506	8	0.019557
MIRNA	MIRNA:hsa-mir-4778-5p	hsa-mir-4778-5p	hsa-mir-4778-5p	11	0.019628
MIRNA	MIRNA:hsa-mir-31	hsa-mir-31	hsa-mir-31	10	0.026576
MIRNA	MIRNA:hsa-mir-33b-5p	hsa-mir-33b-5p	hsa-mir-33b-5p	4	0.026915
MIRNA	MIRNA:hsa-mir-4533	hsa-mir-4533	hsa-mir-4533	13	0.028643
MIRNA	MIRNA:hsa-mir-3606	hsa-mir-3606	hsa-mir-3606	8	0.028836
MIRNA	MIRNA:hsa-mir-6780a-3p	hsa-mir-6780a-3p	hsa-mir-6780a-3p	5	0.029170
MIRNA	MIRNA:hsa-mir-3662	hsa-mir-3662	hsa-mir-3662	15	0.037094
MIRNA	MIRNA:hsa-mir-3668	hsa-mir-3668	hsa-mir-3668	8	0.037156
MIRNA	MIRNA:hsa-mir-583	hsa-mir-583	hsa-mir-583	11	0.043154
MIRNA	MIRNA:hsa-mir-4799-5p	hsa-mir-4799-5p	hsa-mir-4799-5p	11	0.045375
MIRNA	MIRNA:hsa-mir-3686	hsa-mir-3686	hsa-mir-3686	11	0.047021
MIRNA	MIRNA:hsa-mir-4643	hsa-mir-4643	hsa-mir-4643	12	0.049727

source	term_id	annotation	description	intersection_size	p_value
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	29	0.003046
HPA	HPA:0160251	Endometrium 1; cells in endometrial stroma[≥Low]	Endometrium 1; cells in endometrial stroma[≥Low]	25	0.003372
HPA	HPA:0630223	Cervix; squamous epithelial cells[High]	Cervix; squamous epithelial cells[High]	12	0.007155
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	27	0.008387
HPA	HPA:0050052	Breast; glandular cells[≥Medium]	Breast; glandular cells[≥Medium]	27	0.016791
HPA	HPA:0170053	Endometrium 2; glandular cells[High]	Endometrium 2; glandular cells[High]	13	0.018768
HPA	HPA:0250000	Hippocampus	Hippocampus	31	0.028082
HPA	HPA:0620221	Vagina; squamous epithelial cells[≥Low]	Vagina; squamous epithelial cells[≥Low]	29	0.030232
HPA	HPA:0620000	Vagina	Vagina	29	0.030232
HPA	HPA:0340462	Ovary; ovarian stroma cells[≥Medium]	Ovary; ovarian stroma cells[≥Medium]	16	0.032556
HPA	HPA:0050091	Breast; myoepithelial cells[≥Low]	Breast; myoepithelial cells[≥Low]	28	0.036095
HPA	HPA:0080000	Caudate	Caudate	31	0.047381

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0040286	Abnormal axial muscle morphology	A structural anomaly of the muscles of the trunk and head.	2	0.016472	0

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0030125	clathrin vesicle coat	"A clathrin coat found on a vesicle." [GOC:mah]	9	3.208560e-20	1
GO:CC	GO:0030132	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	8	9.542572e-20	1
GO:CC	GO:0005905	clathrin-coated pit	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]	10	1.561780e-19	1
GO:CC	GO:0030118	clathrin coat	"A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]	9	1.376206e-18	1
GO:CC	GO:0030120	vesicle coat	"A membrane coat found on a coated vesicle." [GOC:mah]	9	1.066963e-17	1
GO:CC	GO:0030136	clathrin-coated vesicle	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]	11	4.264477e-17	1
GO:CC	GO:0048475	coated membrane	"A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid]	9	7.723903e-16	1
GO:CC	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	9	7.723903e-16	1
GO:CC	GO:0030135	coated vesicle	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]	11	2.602547e-15	1
GO:CC	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	7	2.748483e-15	1
GO:CC	GO:0030128	clathrin coat of endocytic vesicle	"A clathrin coat found on an endocytic vesicle." [GOC:mah]	6	3.182687e-15	1
GO:CC	GO:0030122	AP-2 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426]	6	3.182687e-15	1
GO:CC	GO:0030665	clathrin-coated vesicle membrane	"The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah]	9	1.380331e-14	1
GO:CC	GO:0045334	clathrin-coated endocytic vesicle	"A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]	8	8.718170e-14	1
GO:CC	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	7	9.916817e-14	1
GO:CC	GO:0036020	endolysosome membrane	"The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]	6	2.660860e-13	1
GO:CC	GO:0030662	coated vesicle membrane	"The lipid bilayer surrounding a coated vesicle." [GOC:mah]	9	5.095467e-13	1
GO:CC	GO:0036019	endolysosome	"An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place." [GOC:pde, PMID:21878991]	6	3.249645e-12	1
GO:CC	GO:0030130	clathrin coat of trans-Golgi network vesicle	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]	5	1.606361e-10	1
GO:CC	GO:0012510	trans-Golgi network transport vesicle membrane	"The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai]	5	2.808805e-10	1
GO:CC	GO:0030669	clathrin-coated endocytic vesicle membrane	"The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah]	6	1.051170e-09	1
GO:CC	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	8	5.979594e-09	1
GO:CC	GO:0030140	trans-Golgi network transport vesicle	"A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]	5	7.888217e-09	1
GO:CC	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	9	1.815791e-08	1
GO:CC	GO:0030660	Golgi-associated vesicle membrane	"The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]	5	6.228525e-08	1
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	11	1.818486e-07	1
GO:CC	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	10	2.660523e-07	1
GO:CC	GO:0012506	vesicle membrane	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]	10	3.079468e-07	1
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	12	4.342298e-07	1
GO:CC	GO:0030666	endocytic vesicle membrane	"The lipid bilayer surrounding an endocytic vesicle." [GOC:mah]	6	6.117196e-07	1
GO:CC	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	10	7.483677e-07	1
GO:CC	GO:0005798	Golgi-associated vesicle	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]	5	8.178718e-07	1
GO:CC	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	6	1.316162e-06	1
GO:CC	GO:0098835	presynaptic endocytic zone membrane	"The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release." [GOC:dos]	3	1.526179e-06	1
GO:CC	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	8	1.827162e-06	1
GO:CC	GO:0098852	lytic vacuole membrane	"The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]	7	1.910384e-06	1
GO:CC	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	7	1.910384e-06	1
GO:CC	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	7	1.969467e-06	1
GO:CC	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	6	2.151558e-06	1
GO:CC	GO:0098833	presynaptic endocytic zone	"A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity." [PMID:17455288]	3	2.440812e-06	1
GO:CC	GO:0005774	vacuolar membrane	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]	7	3.776046e-06	1
GO:CC	GO:0098843	postsynaptic endocytic zone	"A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins." [PMID:17880892]	3	7.182182e-06	1
GO:CC	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	7	1.097334e-05	1
GO:CC	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	5	1.246519e-05	1
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	11	1.678194e-05	1
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	11	1.719746e-05	1
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	14	3.642659e-05	1
GO:CC	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	8	4.074264e-05	1
GO:CC	GO:0098562	cytoplasmic side of membrane	"The side of a membrane that faces the cytoplasm." [GOC:dos]	5	4.139787e-05	1
GO:CC	GO:0099631	postsynaptic endocytic zone cytoplasmic component	"The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos]	2	6.910180e-05	1
GO:CC	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	10	7.326323e-05	1
GO:CC	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	7	7.335668e-05	1
GO:CC	GO:0000323	lytic vacuole	"A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]	7	7.335668e-05	1
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	7	7.933713e-05	1
GO:CC	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	5	1.040559e-04	1
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	12	1.619234e-04	1
GO:CC	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	7	1.629512e-04	1
GO:CC	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	7	7.907913e-04	1
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	12	1.322100e-03	1
GO:CC	GO:0030121	AP-1 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]	2	5.365009e-03	1
GO:CC	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	15	8.003705e-03	1
GO:CC	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	10	9.933389e-03	1
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	16	1.541862e-02	1
GO:CC	GO:0098552	side of membrane	"A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface." [GOC:dos]	5	1.936296e-02	1
GO:CC	GO:0099738	cell cortex region	"The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos]	2	4.291486e-02	1
GO:CC	GO:0042734	presynaptic membrane	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]	3	4.387958e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	9	5.082461e-18	1
GO:BP	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	9	9.871648e-16	1
GO:BP	GO:0140238	presynaptic endocytosis	"A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103]	9	1.538855e-15	1
GO:BP	GO:0036465	synaptic vesicle recycling	"The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane." [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]	9	3.517953e-15	1
GO:BP	GO:0099003	vesicle-mediated transport in synapse	"Any vesicle-mediated transport that occurs in a synapse." [GOC:dos]	10	2.402679e-13	1
GO:BP	GO:0006898	receptor-mediated endocytosis	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]	10	3.153595e-13	1
GO:BP	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	12	1.105763e-12	1
GO:BP	GO:0099504	synaptic vesicle cycle	"A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [GOC:aruk, GOC:bc, PMID:15217342]	9	8.515415e-12	1
GO:BP	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	12	2.567301e-11	1
GO:BP	GO:0140239	postsynaptic endocytosis	"A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988]	6	7.507587e-11	1
GO:BP	GO:0098884	postsynaptic neurotransmitter receptor internalization	"A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle." [GOC:dos]	6	7.507587e-11	1
GO:BP	GO:0099590	neurotransmitter receptor internalization	"A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor." [GOC:dos]	6	2.137960e-10	1
GO:BP	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	13	3.153870e-10	1
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	"Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos]	6	2.077847e-07	1
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	12	2.639454e-07	1
GO:BP	GO:0031623	receptor internalization	"A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]	6	4.225200e-07	1
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	10	4.333270e-06	1
GO:BP	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	6	6.676918e-06	1
GO:BP	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	8	8.755640e-06	1
GO:BP	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	13	1.369327e-04	1
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	12	2.786674e-04	1
GO:BP	GO:0048268	clathrin coat assembly	"The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]	3	3.820068e-04	1
GO:BP	GO:0051234	establishment of localization	"Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]	13	5.534069e-04	1
GO:BP	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	9	1.784225e-03	1
GO:BP	GO:0030100	regulation of endocytosis	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]	5	1.964870e-03	1
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	13	2.447690e-03	1
GO:BP	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	8	2.728559e-03	1
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	10	3.341892e-03	1
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	10	3.479547e-03	1
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	10	1.381678e-02	1
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	8	2.459042e-02	1
GO:BP	GO:0060627	regulation of vesicle-mediated transport	"Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]	5	3.316955e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	7	4.831571e-16	1
REAC	REAC:R-HSA-5099900	WNT5A-dependent internalization of FZD4	WNT5A-dependent internalization of FZD4	7	1.809820e-15	1
REAC	REAC:R-HSA-8856828	Clathrin-mediated endocytosis	Clathrin-mediated endocytosis	10	3.516653e-14	1
REAC	REAC:R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis	9	2.834547e-13	1
REAC	REAC:R-HSA-177504	Retrograde neurotrophin signalling	Retrograde neurotrophin signalling	6	1.160472e-12	1
REAC	REAC:R-HSA-8866427	VLDLR internalisation and degradation	VLDLR internalisation and degradation	6	3.090733e-12	1
REAC	REAC:R-HSA-182218	Nef Mediated CD8 Down-regulation	Nef Mediated CD8 Down-regulation	5	9.953694e-12	1
REAC	REAC:R-HSA-8964038	LDL clearance	LDL clearance	6	1.045216e-11	1
REAC	REAC:R-HSA-437239	Recycling pathway of L1	Recycling pathway of L1	7	2.033002e-11	1
REAC	REAC:R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	6	2.087823e-11	1
REAC	REAC:R-HSA-3928665	EPH-ephrin mediated repulsion of cells	EPH-ephrin mediated repulsion of cells	7	2.370511e-11	1
REAC	REAC:R-HSA-167590	Nef Mediated CD4 Down-regulation	Nef Mediated CD4 Down-regulation	5	5.964073e-11	1
REAC	REAC:R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	The role of Nef in HIV-1 replication and disease pathogenesis	6	1.134648e-10	1
REAC	REAC:R-HSA-8964043	Plasma lipoprotein clearance	Plasma lipoprotein clearance	6	7.424302e-10	1
REAC	REAC:R-HSA-199991	Membrane Trafficking	Membrane Trafficking	11	1.807503e-09	1
REAC	REAC:R-HSA-2682334	EPH-Ephrin signaling	EPH-Ephrin signaling	7	2.015031e-09	1
REAC	REAC:R-HSA-4086400	PCP/CE pathway	PCP/CE pathway	7	2.360076e-09	1
REAC	REAC:R-HSA-5653656	Vesicle-mediated transport	Vesicle-mediated transport	11	8.330406e-09	1
REAC	REAC:R-HSA-373760	L1CAM interactions	L1CAM interactions	7	1.486410e-08	1
REAC	REAC:R-HSA-2132295	MHC class II antigen presentation	MHC class II antigen presentation	7	1.880422e-08	1
REAC	REAC:R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	Plasma lipoprotein assembly, remodeling, and clearance	6	5.340769e-08	1
REAC	REAC:R-HSA-3858494	Beta-catenin independent WNT signaling	Beta-catenin independent WNT signaling	7	5.471566e-08	1
REAC	REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	Signaling by NTRK1 (TRKA)	6	8.234372e-07	1
REAC	REAC:R-HSA-162909	Host Interactions of HIV factors	Host Interactions of HIV factors	6	1.861142e-06	1
REAC	REAC:R-HSA-166520	Signaling by NTRKs	Signaling by NTRKs	6	2.142973e-06	1
REAC	REAC:R-HSA-195721	Signaling by WNT	Signaling by WNT	7	1.753974e-05	1
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	8	2.455652e-05	1
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	8	3.483817e-05	1
REAC	REAC:R-HSA-162906	HIV Infection	HIV Infection	6	5.854319e-05	1
REAC	REAC:R-HSA-196025	Formation of annular gap junctions	Formation of annular gap junctions	3	8.563807e-05	1
REAC	REAC:R-HSA-190873	Gap junction degradation	Gap junction degradation	3	1.140985e-04	1
REAC	REAC:R-HSA-9679191	Potential therapeutics for SARS	Potential therapeutics for SARS	5	2.542437e-04	1
REAC	REAC:R-HSA-199992	trans-Golgi Network Vesicle Budding	trans-Golgi Network Vesicle Budding	4	5.404001e-04	1
REAC	REAC:R-HSA-432720	Lysosome Vesicle Biogenesis	Lysosome Vesicle Biogenesis	3	3.636907e-03	1
REAC	REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	Signaling by Receptor Tyrosine Kinases	6	7.155294e-03	1
REAC	REAC:R-HSA-1280218	Adaptive Immune System	Adaptive Immune System	7	7.881636e-03	1
REAC	REAC:R-HSA-190828	Gap junction trafficking	Gap junction trafficking	3	9.293485e-03	1
REAC	REAC:R-HSA-157858	Gap junction trafficking and regulation	Gap junction trafficking and regulation	3	9.879264e-03	1
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	7	1.285088e-02	1
REAC	REAC:R-HSA-1266738	Developmental Biology	Developmental Biology	8	2.907945e-02	1
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	7	4.544608e-02	1
REAC	REAC:R-HSA-382551	Transport of small molecules	Transport of small molecules	6	4.996694e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0035615	clathrin adaptor activity	"Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]	6	4.093689e-13	1
GO:MF	GO:0140312	cargo adaptor activity	"Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]	6	1.195096e-12	1
GO:MF	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	5	1.992431e-07	1
GO:MF	GO:0032050	clathrin heavy chain binding	"Binding to a clathrin heavy chain." [GOC:mah]	2	8.484433e-03	1
GO:MF	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	4	1.034522e-02	1
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	6	2.380386e-02	1
GO:MF	GO:0050750	low-density lipoprotein particle receptor binding	"Binding to a low-density lipoprotein receptor." [GOC:ai]	2	4.598100e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	Endocrine and other factor-regulated calcium reabsorption	7	4.666410e-12	1
KEGG	KEGG:04721	Synaptic vesicle cycle	Synaptic vesicle cycle	7	7.915278e-11	1
KEGG	KEGG:04144	Endocytosis	Endocytosis	7	2.932359e-07	1
KEGG	KEGG:05016	Huntington disease	Huntington disease	7	1.237764e-06	1
KEGG	KEGG:04142	Lysosome	Lysosome	3	3.174636e-02	1

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP2267	Synaptic vesicle pathway	Synaptic vesicle pathway	6	1.723093e-09	1
WP	WP:WP4159	GABA receptor signaling	GABA receptor signaling	5	2.387109e-08	1
WP	WP:WP4549	Fragile X syndrome	Fragile X syndrome	6	3.552280e-07	1
WP	WP:WP437	EGF EGFR signaling	EGF EGFR signaling	5	1.005161e-04	1
WP	WP:WP4829	mBDNF and proBDNF regulation of GABA neurotransmission	mBDNF and proBDNF regulation of GABA neurotransmission	3	1.605069e-03	1

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:247	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex	3	0.000002	1

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-34a-5p	hsa-mir-34a-5p	hsa-mir-34a-5p	6	0.004586	1

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0100212	Cerebral cortex; neuropil[≥Medium]	Cerebral cortex; neuropil[≥Medium]	10	0.010932	1
HPA	HPA:0570742	Testis; cells in seminiferous ducts[≥Medium]	Testis; cells in seminiferous ducts[≥Medium]	9	0.039887	1

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:1530	Girdin homo-oligomer complex	Girdin homo-oligomer complex	1	0.049932	2

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0030142	COPI-coated Golgi to ER transport vesicle	"A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah, PMID:22160157]	1	0.04998	2

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-193b-3p	hsa-mir-193b-3p	hsa-mir-193b-3p	5	0.000101	3

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	4	0.003056	3
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	3	0.015188	3
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	3	0.016274	3
GO:CC	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	3	0.028433	3
GO:CC	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	3	0.029736	3
GO:CC	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	3	0.042432	3
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	5	0.044193	3

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04015	Rap1 signaling pathway	Rap1 signaling pathway	3	0.003154	3

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	3	0.008868	3
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	3	0.041746	3

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0032535	regulation of cellular component size	"A process that modulates the size of a cellular component." [GOC:mah]	3	0.012675	3
GO:BP	GO:0030838	positive regulation of actin filament polymerization	"Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah]	2	0.023920	3
GO:BP	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	3	0.027471	3
GO:BP	GO:0090066	regulation of anatomical structure size	"Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb]	3	0.035018	3

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	4	0.000517	4
KEGG	KEGG:05020	Prion disease	Prion disease	3	0.006762	4
KEGG	KEGG:03050	Proteasome	Proteasome	2	0.009204	4
KEGG	KEGG:05016	Huntington disease	Huntington disease	3	0.009623	4
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	Amyotrophic lateral sclerosis	3	0.016162	4

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	2	0.000780	4
GO:CC	GO:0022624	proteasome accessory complex	"A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]	2	0.001012	4
GO:CC	GO:0000502	proteasome complex	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome]	2	0.007441	4
GO:CC	GO:1905369	endopeptidase complex	"A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	2	0.016961	4
GO:CC	GO:1905368	peptidase complex	"A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	2	0.028113	4

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-69275	G2/M Transition	G2/M Transition	3	0.003724	4
REAC	REAC:R-HSA-453274	Mitotic G2-G2/M phases	Mitotic G2-G2/M phases	3	0.003839	4
REAC	REAC:R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	Cross-presentation of soluble exogenous antigens (endosomes)	2	0.019643	4
REAC	REAC:R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	Regulation of activated PAK-2p34 by proteasome mediated degradation	2	0.020459	4
REAC	REAC:R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	Regulation of ornithine decarboxylase (ODC)	2	0.021291	4
REAC	REAC:R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	2	0.022140	4
REAC	REAC:R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	Ubiquitin-dependent degradation of Cyclin D	2	0.022140	4
REAC	REAC:R-HSA-69610	p53-Independent DNA Damage Response	p53-Independent DNA Damage Response	2	0.022140	4
REAC	REAC:R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	p53-Independent G1/S DNA damage checkpoint	2	0.022140	4
REAC	REAC:R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	Autodegradation of the E3 ubiquitin ligase COP1	2	0.022140	4
REAC	REAC:R-HSA-180534	Vpu mediated degradation of CD4	Vpu mediated degradation of CD4	2	0.022140	4
REAC	REAC:R-HSA-9762114	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	2	0.022140	4
REAC	REAC:R-HSA-9604323	Negative regulation of NOTCH4 signaling	Negative regulation of NOTCH4 signaling	2	0.023005	4
REAC	REAC:R-HSA-169911	Regulation of Apoptosis	Regulation of Apoptosis	2	0.023005	4
REAC	REAC:R-HSA-180585	Vif-mediated degradation of APOBEC3G	Vif-mediated degradation of APOBEC3G	2	0.023005	4
REAC	REAC:R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	AUF1 (hnRNP D0) binds and destabilizes mRNA	2	0.023887	4
REAC	REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	Regulation of RUNX3 expression and activity	2	0.024786	4
REAC	REAC:R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	2	0.024786	4
REAC	REAC:R-HSA-9824272	Somitogenesis	Somitogenesis	2	0.024786	4
REAC	REAC:R-HSA-4641257	Degradation of AXIN	Degradation of AXIN	2	0.024786	4
REAC	REAC:R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	SCF-beta-TrCP mediated degradation of Emi1	2	0.024786	4
REAC	REAC:R-HSA-5362768	Hh mutants are degraded by ERAD	Hh mutants are degraded by ERAD	2	0.025701	4
REAC	REAC:R-HSA-69541	Stabilization of p53	Stabilization of p53	2	0.026632	4
REAC	REAC:R-HSA-4641258	Degradation of DVL	Degradation of DVL	2	0.026632	4
REAC	REAC:R-HSA-351202	Metabolism of polyamines	Metabolism of polyamines	2	0.027580	4
REAC	REAC:R-HSA-5676590	NIK-->noncanonical NF-kB signaling	NIK-->noncanonical NF-kB signaling	2	0.028544	4
REAC	REAC:R-HSA-5387390	Hh mutants abrogate ligand secretion	Hh mutants abrogate ligand secretion	2	0.028544	4
REAC	REAC:R-HSA-5610780	Degradation of GLI1 by the proteasome	Degradation of GLI1 by the proteasome	2	0.029525	4
REAC	REAC:R-HSA-5610783	Degradation of GLI2 by the proteasome	Degradation of GLI2 by the proteasome	2	0.029525	4
REAC	REAC:R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	Dectin-1 mediated noncanonical NF-kB signaling	2	0.029525	4
REAC	REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	SCF(Skp2)-mediated degradation of p27/p21	2	0.029525	4
REAC	REAC:R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	GLI3 is processed to GLI3R by the proteasome	2	0.029525	4
REAC	REAC:R-HSA-5678895	Defective CFTR causes cystic fibrosis	Defective CFTR causes cystic fibrosis	2	0.030522	4
REAC	REAC:R-HSA-68886	M Phase	M Phase	3	0.033122	4
REAC	REAC:R-HSA-4608870	Asymmetric localization of PCP proteins	Asymmetric localization of PCP proteins	2	0.033612	4
REAC	REAC:R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	Autodegradation of Cdh1 by Cdh1:APC/C	2	0.033612	4
REAC	REAC:R-HSA-5358346	Hedgehog ligand biogenesis	Hedgehog ligand biogenesis	2	0.034674	4
REAC	REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	p53-Dependent G1/S DNA damage checkpoint	2	0.035754	4
REAC	REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	p53-Dependent G1 DNA Damage Response	2	0.035754	4
REAC	REAC:R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	2	0.035754	4
REAC	REAC:R-HSA-1169091	Activation of NF-kappaB in B cells	Activation of NF-kappaB in B cells	2	0.036849	4
REAC	REAC:R-HSA-5658442	Regulation of RAS by GAPs	Regulation of RAS by GAPs	2	0.036849	4
REAC	REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	G1/S DNA Damage Checkpoints	2	0.037961	4
REAC	REAC:R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	APC/C:Cdc20 mediated degradation of Securin	2	0.037961	4
REAC	REAC:R-HSA-8948751	Regulation of PTEN stability and activity	Regulation of PTEN stability and activity	2	0.039090	4
REAC	REAC:R-HSA-9793380	Formation of paraxial mesoderm	Formation of paraxial mesoderm	2	0.039090	4
REAC	REAC:R-HSA-8939902	Regulation of RUNX2 expression and activity	Regulation of RUNX2 expression and activity	2	0.041396	4
REAC	REAC:R-HSA-68949	Orc1 removal from chromatin	Orc1 removal from chromatin	2	0.041396	4
REAC	REAC:R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	2	0.043767	4
REAC	REAC:R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	CDK-mediated phosphorylation and removal of Cdc6	2	0.043767	4
REAC	REAC:R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	2	0.044977	4
REAC	REAC:R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	2	0.044977	4
REAC	REAC:R-HSA-1234174	Cellular response to hypoxia	Cellular response to hypoxia	2	0.046204	4
REAC	REAC:R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	APC/C:Cdc20 mediated degradation of mitotic proteins	2	0.047447	4
REAC	REAC:R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	2	0.048706	4
REAC	REAC:R-HSA-5619084	ABC transporter disorders	ABC transporter disorders	2	0.049982	4

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:32	PA700 complex	PA700 complex	2	0.005597	4
CORUM	CORUM:193	PA700-20S-PA28 complex	PA700-20S-PA28 complex	2	0.015513	4
CORUM	CORUM:1088	PRNP-ApolopoproteinE3 complex	PRNP-ApolopoproteinE3 complex	1	0.049988	4
CORUM	CORUM:2007	PRNP homo-oligomer complex	PRNP homo-oligomer complex	1	0.049988	4

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP183	Proteasome degradation	Proteasome degradation	2	0.024796	4
WP	WP:WP2359	Parkin ubiquitin proteasomal system pathway	Parkin ubiquitin proteasomal system pathway	2	0.032540	4

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	4	0.033986	4

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M07091	Factor: Fra-1; motif: RRTGASTCAKN	Factor: Fra-1; motif: RRTGASTCAKN	4	0.044515	4

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0006790	Cerebral cortex with spongiform changes	Cerebral cortex with spongiform changes	1	0.049962	4
HP	HP:0010542	Vestibular nystagmus	Nystagmus due to disturbance of the vestibular system; eye movements are rhythmic, with slow and fast components.	1	0.049962	4
HP	HP:0012660	Thalamic hypometabolism in FDG PET	Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the thalamus as measured by positron emission tomography (PET) brain scan.	1	0.049962	4
HP	HP:0040200	Motor impersistence	The inability to maintain postures or positions (such as keeping eyes closed, protruding the tongue, maintaining conjugate gaze steadily in a fixed direction, or making a prolonged 'ah' sound) without repeated prompts.	1	0.049962	4
HP	HP:0040201	Simultanapraxia	A subset of motor impersistence, defined as the inability to perform more than two of the simple voluntary acts simultaneously, such as closing the eyes and protruding the tongue.	1	0.049962	4

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0072385	minus-end-directed organelle transport along microtubule	"The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah]	2	0.000014	5
GO:BP	GO:0072393	microtubule anchoring at microtubule organizing center	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938]	2	0.000214	5
GO:BP	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	2	0.000766	5
GO:BP	GO:0072384	organelle transport along microtubule	"The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]	2	0.009437	5
GO:BP	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	2	0.031495	5
GO:BP	GO:0010970	transport along microtubule	"The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]	2	0.037119	5
GO:BP	GO:0006403	RNA localization	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]	2	0.046891	5

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0034452	dynactin binding	"Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah]	2	0.000324	5
GO:MF	GO:0008093	cytoskeletal anchor activity	"The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238]	2	0.001355	5
GO:MF	GO:0070840	dynein complex binding	"Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]	2	0.001473	5

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	COPI-independent Golgi-to-ER retrograde traffic	2	0.006253	5
REAC	REAC:R-HSA-8856688	Golgi-to-ER retrograde transport	Golgi-to-ER retrograde transport	2	0.039835	5

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:03250	Viral life cycle - HIV-1	Viral life cycle - HIV-1	2	0.007768	5

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP2380	Brain derived neurotrophic factor BDNF signaling	Brain derived neurotrophic factor BDNF signaling	2	0.047148	8

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:7011	FERMT3-RACK1 complex	FERMT3-RACK1 complex	1	0.049932	8
CORUM	CORUM:7012	ITGB1-RACK1 complex	ITGB1-RACK1 complex	1	0.049932	8
CORUM	CORUM:7013	ITGB2-RACK1 complex	ITGB2-RACK1 complex	1	0.049932	8

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:1990630	IRE1-RACK1-PP2A complex	"A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A." [GOC:bf, GOC:PARL, PMID:20103773]	1	0.049978	8

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5224	2q37 copy number variation syndrome	2q37 copy number variation syndrome	2	0.011366	9

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-5586-5p	hsa-mir-5586-5p	hsa-mir-5586-5p	2	0.001944	11
MIRNA	MIRNA:hsa-mir-1247-3p	hsa-mir-1247-3p	hsa-mir-1247-3p	2	0.027180	11
MIRNA	MIRNA:hsa-mir-5589-5p	hsa-mir-5589-5p	hsa-mir-5589-5p	2	0.047942	11

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:6122	Hook3-Vps16 complex	Hook3-Vps16 complex	1	0.049932	11
CORUM	CORUM:6123	Hook3-Vps41 complex	Hook3-Vps41 complex	1	0.049932	11

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP2366	Butyrate induced histone acetylation	Butyrate induced histone acetylation	1	0.012487	12

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0003878	ATP citrate synthase activity	"Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA." [RHEA:21160]	1	0.049891	12

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP661	Glucose homeostasis	Glucose homeostasis	1	0.006244	13
WP	WP:WP5452	GLP 1 from intestine and pancreas and role in glucose homeostasis	GLP 1 from intestine and pancreas and role in glucose homeostasis	1	0.037462	13
WP	WP:WP5447	GLP 1 in pancreatic islet cells	GLP 1 in pancreatic islet cells	1	0.043706	13

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	2	0.008928	13
GO:CC	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	2	0.045450	13
GO:CC	GO:0034774	secretory granule lumen	"The volume enclosed by the membrane of a secretory granule." [GOC:rph]	2	0.048406	13
GO:CC	GO:0060205	cytoplasmic vesicle lumen	"The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]	2	0.049918	13

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04950	Maturity onset diabetes of the young	Maturity onset diabetes of the young	1	0.049912	13

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0032938	negative regulation of translation in response to oxidative stress	"Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	1	0.049542	14
GO:BP	GO:0043556	regulation of translation in response to oxidative stress	"Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]	1	0.049542	14

biogrid+hippie (Louvain)

View:

Community 0

GO:BP

source	term_id	annotation	description	intersection_size	p_value
GO:BP	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	7	0.000306
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	9	0.002713
GO:BP	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	6	0.010263
GO:BP	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	6	0.011176
GO:BP	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	6	0.011176
GO:BP	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	5	0.016240
GO:BP	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	7	0.017373
GO:BP	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	4	0.018145
GO:BP	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	8	0.030599
GO:BP	GO:0016049	cell growth	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]	6	0.030713
GO:BP	GO:1903829	positive regulation of protein localization	"Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	6	0.036065
GO:BP	GO:0009057	macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	9	0.036647

GO:CC

source	term_id	annotation	description	intersection_size	p_value
GO:CC	GO:0031974	membrane-enclosed lumen	"The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]	16	0.048163
GO:CC	GO:0043233	organelle lumen	"The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]	16	0.048163
GO:CC	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	16	0.048163

Community 1

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0030125	clathrin vesicle coat	"A clathrin coat found on a vesicle." [GOC:mah]	11	6.587901e-24	1
GO:CC	GO:0005905	clathrin-coated pit	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]	12	3.089461e-22	1
GO:CC	GO:0030118	clathrin coat	"A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]	11	7.460404e-22	1
GO:CC	GO:0030132	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	9	3.952925e-21	1
GO:CC	GO:0030136	clathrin-coated vesicle	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]	14	8.409192e-21	1
GO:CC	GO:0030120	vesicle coat	"A membrane coat found on a coated vesicle." [GOC:mah]	11	9.588623e-21	1
GO:CC	GO:0030135	coated vesicle	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]	14	1.606380e-18	1
GO:CC	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	11	1.927866e-18	1
GO:CC	GO:0048475	coated membrane	"A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid]	11	1.927866e-18	1
GO:CC	GO:0030665	clathrin-coated vesicle membrane	"The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah]	11	6.722601e-17	1
GO:CC	GO:0045334	clathrin-coated endocytic vesicle	"A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]	10	1.326537e-16	1
GO:CC	GO:0030662	coated vesicle membrane	"The lipid bilayer surrounding a coated vesicle." [GOC:mah]	11	5.639139e-15	1
GO:CC	GO:0036020	endolysosome membrane	"The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]	7	6.758771e-15	1
GO:CC	GO:0030128	clathrin coat of endocytic vesicle	"A clathrin coat found on an endocytic vesicle." [GOC:mah]	6	5.272608e-14	1
GO:CC	GO:0030122	AP-2 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426]	6	5.272608e-14	1
GO:CC	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	7	7.708287e-14	1
GO:CC	GO:0036019	endolysosome	"An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place." [GOC:pde, PMID:21878991]	7	1.353076e-13	1
GO:CC	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	7	2.768934e-12	1
GO:CC	GO:0030130	clathrin coat of trans-Golgi network vesicle	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]	6	3.080192e-12	1
GO:CC	GO:0012510	trans-Golgi network transport vesicle membrane	"The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai]	6	6.152276e-12	1
GO:CC	GO:0030669	clathrin-coated endocytic vesicle membrane	"The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah]	7	1.242765e-10	1
GO:CC	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	10	1.557100e-10	1
GO:CC	GO:0030140	trans-Golgi network transport vesicle	"A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]	6	3.655458e-10	1
GO:CC	GO:0030660	Golgi-associated vesicle membrane	"The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]	6	4.478452e-09	1
GO:CC	GO:0005798	Golgi-associated vesicle	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]	6	1.000360e-07	1
GO:CC	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	12	1.420045e-07	1
GO:CC	GO:0012506	vesicle membrane	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]	12	1.687180e-07	1
GO:CC	GO:0030666	endocytic vesicle membrane	"The lipid bilayer surrounding an endocytic vesicle." [GOC:mah]	7	2.110362e-07	1
GO:CC	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	12	4.799414e-07	1
GO:CC	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	9	1.423232e-06	1
GO:CC	GO:0098852	lytic vacuole membrane	"The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]	8	1.936249e-06	1
GO:CC	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	8	1.936249e-06	1
GO:CC	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	8	2.004121e-06	1
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	14	3.949515e-06	1
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	14	4.071305e-06	1
GO:CC	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	9	4.132153e-06	1
GO:CC	GO:0005774	vacuolar membrane	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]	8	4.182816e-06	1
GO:CC	GO:0098835	presynaptic endocytic zone membrane	"The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release." [GOC:dos]	3	6.345634e-06	1
GO:CC	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	13	9.512179e-06	1
GO:CC	GO:0098833	presynaptic endocytic zone	"A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity." [PMID:17455288]	3	1.014614e-05	1
GO:CC	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	8	1.393832e-05	1
GO:CC	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	6	2.052816e-05	1
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	13	2.057525e-05	1
GO:CC	GO:0098843	postsynaptic endocytic zone	"A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins." [PMID:17880892]	3	2.983417e-05	1
GO:CC	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	6	3.337563e-05	1
GO:CC	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	6	3.337563e-05	1
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	11	4.517330e-05	1
GO:CC	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	8	1.179268e-04	1
GO:CC	GO:0000323	lytic vacuole	"A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]	8	1.179268e-04	1
GO:CC	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	5	1.211475e-04	1
GO:CC	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	9	1.260681e-04	1
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	15	1.615775e-04	1
GO:CC	GO:0099631	postsynaptic endocytic zone cytoplasmic component	"The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos]	2	1.917254e-04	1
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	17	2.129863e-04	1
GO:CC	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	8	2.881065e-04	1
GO:CC	GO:0098562	cytoplasmic side of membrane	"The side of a membrane that faces the cytoplasm." [GOC:dos]	5	3.975906e-04	1
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	7	1.803443e-03	1
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	15	1.953013e-03	1
GO:CC	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	13	4.713398e-03	1
GO:CC	GO:0071439	clathrin complex	"A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411]	2	5.347984e-03	1
GO:CC	GO:0030121	AP-1 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]	2	1.485094e-02	1
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	23	1.549527e-02	1
GO:CC	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	7	1.642078e-02	1
GO:CC	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	15	2.064056e-02	1
GO:CC	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	4	2.877865e-02	1
GO:CC	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	8	3.198606e-02	1
GO:CC	GO:0032588	trans-Golgi network membrane	"The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]	3	3.552148e-02	1
GO:CC	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	19	4.463312e-02	1

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-5099900	WNT5A-dependent internalization of FZD4	WNT5A-dependent internalization of FZD4	9	2.298882e-20	1
REAC	REAC:R-HSA-8856828	Clathrin-mediated endocytosis	Clathrin-mediated endocytosis	13	1.720973e-18	1
REAC	REAC:R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis	12	4.620339e-18	1
REAC	REAC:R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	8	5.912013e-18	1
REAC	REAC:R-HSA-177504	Retrograde neurotrophin signalling	Retrograde neurotrophin signalling	7	1.441533e-14	1
REAC	REAC:R-HSA-8866427	VLDLR internalisation and degradation	VLDLR internalisation and degradation	7	4.795933e-14	1
REAC	REAC:R-HSA-8964038	LDL clearance	LDL clearance	7	2.106341e-13	1
REAC	REAC:R-HSA-437239	Recycling pathway of L1	Recycling pathway of L1	8	1.680183e-12	1
REAC	REAC:R-HSA-3928665	EPH-ephrin mediated repulsion of cells	EPH-ephrin mediated repulsion of cells	8	2.006233e-12	1
REAC	REAC:R-HSA-4086400	PCP/CE pathway	PCP/CE pathway	9	3.745723e-12	1
REAC	REAC:R-HSA-199991	Membrane Trafficking	Membrane Trafficking	14	9.157958e-12	1
REAC	REAC:R-HSA-8964043	Plasma lipoprotein clearance	Plasma lipoprotein clearance	7	3.433250e-11	1
REAC	REAC:R-HSA-182218	Nef Mediated CD8 Down-regulation	Nef Mediated CD8 Down-regulation	5	5.889451e-11	1
REAC	REAC:R-HSA-5653656	Vesicle-mediated transport	Vesicle-mediated transport	14	6.363840e-11	1
REAC	REAC:R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	6	1.911867e-10	1
REAC	REAC:R-HSA-3858494	Beta-catenin independent WNT signaling	Beta-catenin independent WNT signaling	9	2.203178e-10	1
REAC	REAC:R-HSA-2682334	EPH-Ephrin signaling	EPH-Ephrin signaling	8	3.324342e-10	1
REAC	REAC:R-HSA-167590	Nef Mediated CD4 Down-regulation	Nef Mediated CD4 Down-regulation	5	3.526178e-10	1
REAC	REAC:R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	The role of Nef in HIV-1 replication and disease pathogenesis	6	1.036593e-09	1
REAC	REAC:R-HSA-373760	L1CAM interactions	L1CAM interactions	8	3.277086e-09	1
REAC	REAC:R-HSA-2132295	MHC class II antigen presentation	MHC class II antigen presentation	8	4.288075e-09	1
REAC	REAC:R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	Plasma lipoprotein assembly, remodeling, and clearance	7	5.289217e-09	1
REAC	REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	Signaling by NTRK1 (TRKA)	7	1.299882e-07	1
REAC	REAC:R-HSA-195721	Signaling by WNT	Signaling by WNT	9	3.738840e-07	1
REAC	REAC:R-HSA-166520	Signaling by NTRKs	Signaling by NTRKs	7	3.969784e-07	1
REAC	REAC:R-HSA-196025	Formation of annular gap junctions	Formation of annular gap junctions	4	6.749540e-07	1
REAC	REAC:R-HSA-190873	Gap junction degradation	Gap junction degradation	4	1.011326e-06	1
REAC	REAC:R-HSA-162909	Host Interactions of HIV factors	Host Interactions of HIV factors	6	1.635065e-05	1
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	9	3.125916e-05	1
REAC	REAC:R-HSA-199992	trans-Golgi Network Vesicle Budding	trans-Golgi Network Vesicle Budding	5	3.927044e-05	1
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	9	4.601822e-05	1
REAC	REAC:R-HSA-432720	Lysosome Vesicle Biogenesis	Lysosome Vesicle Biogenesis	4	1.172343e-04	1
REAC	REAC:R-HSA-190828	Gap junction trafficking	Gap junction trafficking	4	4.157334e-04	1
REAC	REAC:R-HSA-157858	Gap junction trafficking and regulation	Gap junction trafficking and regulation	4	4.513905e-04	1
REAC	REAC:R-HSA-162906	HIV Infection	HIV Infection	6	4.946942e-04	1
REAC	REAC:R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	Entry of Influenza Virion into Host Cell via Endocytosis	2	9.170937e-04	1
REAC	REAC:R-HSA-1280218	Adaptive Immune System	Adaptive Immune System	9	9.286507e-04	1
REAC	REAC:R-HSA-9679191	Potential therapeutics for SARS	Potential therapeutics for SARS	5	1.424778e-03	1
REAC	REAC:R-HSA-382551	Transport of small molecules	Transport of small molecules	8	4.548099e-03	1
REAC	REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	Signaling by Receptor Tyrosine Kinases	7	4.784378e-03	1
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	9	8.611092e-03	1
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	8	1.690515e-02	1

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	10	1.488304e-18	1
GO:BP	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	9	1.183422e-13	1
GO:BP	GO:0140238	presynaptic endocytosis	"A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103]	9	1.842575e-13	1
GO:BP	GO:0036465	synaptic vesicle recycling	"The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane." [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]	9	4.202160e-13	1
GO:BP	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	14	8.995221e-13	1
GO:BP	GO:0006898	receptor-mediated endocytosis	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]	11	1.032889e-12	1
GO:BP	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	14	3.389780e-11	1
GO:BP	GO:0099003	vesicle-mediated transport in synapse	"Any vesicle-mediated transport that occurs in a synapse." [GOC:dos]	10	5.918933e-11	1
GO:BP	GO:0099504	synaptic vesicle cycle	"A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [GOC:aruk, GOC:bc, PMID:15217342]	9	9.792490e-10	1
GO:BP	GO:0098884	postsynaptic neurotransmitter receptor internalization	"A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle." [GOC:dos]	6	1.369360e-09	1
GO:BP	GO:0140239	postsynaptic endocytosis	"A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988]	6	1.369360e-09	1
GO:BP	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	15	2.473340e-09	1
GO:BP	GO:0099590	neurotransmitter receptor internalization	"A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor." [GOC:dos]	6	3.892889e-09	1
GO:BP	GO:0031623	receptor internalization	"A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]	7	1.062608e-07	1
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	14	1.296959e-06	1
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	17	2.164481e-06	1
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	"Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos]	6	3.696788e-06	1
GO:BP	GO:0048268	clathrin coat assembly	"The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]	4	5.745015e-06	1
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	15	6.872653e-06	1
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	15	7.303088e-06	1
GO:BP	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	9	2.252720e-05	1
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	11	5.651508e-05	1
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	15	5.819733e-05	1
GO:BP	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	11	8.956036e-05	1
GO:BP	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	6	1.156354e-04	1
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	18	1.491677e-04	1
GO:BP	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	12	1.491982e-04	1
GO:BP	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	16	4.550671e-04	1
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	11	1.775584e-03	1
GO:BP	GO:0051234	establishment of localization	"Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]	16	2.287694e-03	1
GO:BP	GO:1903077	negative regulation of protein localization to plasma membrane	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]	3	6.605240e-03	1
GO:BP	GO:1904376	negative regulation of protein localization to cell periphery	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]	3	8.058522e-03	1
GO:BP	GO:1900126	negative regulation of hyaluronan biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]	2	1.043754e-02	1
GO:BP	GO:1905476	negative regulation of protein localization to membrane	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	3	1.477786e-02	1
GO:BP	GO:0030100	regulation of endocytosis	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]	5	1.959377e-02	1
GO:BP	GO:1900125	regulation of hyaluronan biosynthetic process	"Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]	2	4.858511e-02	1
GO:BP	GO:0072318	clathrin coat disassembly	"The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system." [PMID:11084334, PMID:11146663, PMID:8524399]	2	4.858511e-02	1

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	Endocrine and other factor-regulated calcium reabsorption	8	2.248637e-13	1
KEGG	KEGG:04721	Synaptic vesicle cycle	Synaptic vesicle cycle	8	5.855179e-12	1
KEGG	KEGG:04144	Endocytosis	Endocytosis	8	7.092928e-08	1
KEGG	KEGG:05016	Huntington disease	Huntington disease	8	3.655472e-07	1
KEGG	KEGG:04142	Lysosome	Lysosome	4	2.780057e-03	1
KEGG	KEGG:05100	Bacterial invasion of epithelial cells	Bacterial invasion of epithelial cells	3	1.404297e-02	1

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0035615	clathrin adaptor activity	"Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]	6	6.611236e-12	1
GO:MF	GO:0140312	cargo adaptor activity	"Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]	6	1.928343e-11	1
GO:MF	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	6	1.557911e-08	1
GO:MF	GO:0050750	low-density lipoprotein particle receptor binding	"Binding to a low-density lipoprotein receptor." [GOC:ai]	3	9.856330e-04	1
GO:MF	GO:0097718	disordered domain specific binding	"Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698]	3	1.561236e-03	1
GO:MF	GO:0070325	lipoprotein particle receptor binding	"Binding to a lipoprotein particle receptor." [GOC:BHF, GOC:rl]	3	1.733422e-03	1
GO:MF	GO:0032050	clathrin heavy chain binding	"Binding to a clathrin heavy chain." [GOC:mah]	2	2.295120e-02	1
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	7	3.598660e-02	1

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP2267	Synaptic vesicle pathway	Synaptic vesicle pathway	7	1.255094e-10	1
WP	WP:WP4549	Fragile X syndrome	Fragile X syndrome	8	8.525596e-10	1
WP	WP:WP4159	GABA receptor signaling	GABA receptor signaling	5	1.582223e-07	1
WP	WP:WP437	EGF EGFR signaling	EGF EGFR signaling	6	1.871716e-05	1
WP	WP:WP4829	mBDNF and proBDNF regulation of GABA neurotransmission	mBDNF and proBDNF regulation of GABA neurotransmission	3	4.503996e-03	1

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:247	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex	3	0.000013	1

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M00007	Factor: Elk-1; motif: NAAACMGGAAGTNCVH	Factor: Elk-1; motif: NAAACMGGAAGTNCVH	18	0.003513	1

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-34a-5p	hsa-mir-34a-5p	hsa-mir-34a-5p	6	0.039129	1
MIRNA	MIRNA:hsa-mir-6780a-3p	hsa-mir-6780a-3p	hsa-mir-6780a-3p	4	0.049190	1

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0100212	Cerebral cortex; neuropil[≥Medium]	Cerebral cortex; neuropil[≥Medium]	12	0.045888	1

Community 2

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	12	0.000012	2
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	12	0.000015	2
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	12	0.000015	2
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	12	0.000015	2
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	17	0.000020	2
GO:CC	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]	9	0.000309	2
GO:CC	GO:0036477	somatodendritic compartment	"The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]	7	0.001649	2
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	12	0.001703	2
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	13	0.001958	2
GO:CC	GO:0072357	PTW/PP1 phosphatase complex	"A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061]	2	0.003156	2
GO:CC	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	10	0.003296	2
GO:CC	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	6	0.003555	2
GO:CC	GO:0097447	dendritic tree	"The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]	6	0.003618	2
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	13	0.003626	2
GO:CC	GO:0043197	dendritic spine	"A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]	4	0.003903	2
GO:CC	GO:0044309	neuron spine	"A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102]	4	0.004257	2
GO:CC	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	6	0.004421	2
GO:CC	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]	10	0.005107	2
GO:CC	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	3	0.007707	2
GO:CC	GO:0120111	neuron projection cytoplasm	"All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha]	3	0.013935	2
GO:CC	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	5	0.015262	2
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	20	0.019022	2
GO:CC	GO:0150034	distal axon	"That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468]	4	0.022538	2
GO:CC	GO:0000164	protein phosphatase type 1 complex	"A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd]	2	0.025526	2
GO:CC	GO:0044297	cell body	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]	5	0.027769	2
GO:CC	GO:0034774	secretory granule lumen	"The volume enclosed by the membrane of a secretory granule." [GOC:rph]	4	0.038447	2
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	9	0.039272	2
GO:CC	GO:0060205	cytoplasmic vesicle lumen	"The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]	4	0.040770	2
GO:CC	GO:0031983	vesicle lumen	"The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]	4	0.041246	2
GO:CC	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	7	0.045601	2

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0008157	protein phosphatase 1 binding	"Binding to a protein phosphatase 1." [GOC:jl]	3	0.000699	2
GO:MF	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	4	0.004404	2
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	10	0.005593	2
GO:MF	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	8	0.009371	2
GO:MF	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	4	0.012985	2
GO:MF	GO:0005521	lamin binding	"Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732]	2	0.039067	2

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0008088	axo-dendritic transport	"The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194]	4	0.001681	2
GO:BP	GO:1900271	regulation of long-term synaptic potentiation	"Any process that modulates the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie]	3	0.017555	2
GO:BP	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	6	0.018189	2
GO:BP	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]	7	0.018590	2
GO:BP	GO:0010970	transport along microtubule	"The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]	4	0.034903	2

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	7	0.001856	2
KEGG	KEGG:05205	Proteoglycans in cancer	Proteoglycans in cancer	4	0.047741	2

HP

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0002185	Neurofibrillary tangles	Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form.	3	0.010918	2
HP	HP:0007158	Progressive extrapyramidal muscular rigidity	A progressive degree of muscular rigidity (continuous contraction of muscles with constant resistance to passive movement).	2	0.027481	2
HP	HP:0002549	Deficit in phonologic short-term memory	Impaired ability to repeat non-word sounds. The test for nonword repetition involves the repetition of nonsensical words of increasing length and complexity and is regarded as a measure of phonological (speech sound) processing and short-term memory	2	0.045753	2

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP4861	Endoplasmic reticulum stress response in coronavirus infection	Endoplasmic reticulum stress response in coronavirus infection	3	0.018045	2
WP	WP:WP3286	Copper homeostasis	Copper homeostasis	3	0.024586	2
WP	WP:WP5120	Inclusion body myositis	Inclusion body myositis	2	0.028906	2
WP	WP:WP5265	Neurogenesis regulation in the olfactory epithelium	Neurogenesis regulation in the olfactory epithelium	3	0.034261	2
WP	WP:WP2814	Mammary gland development puberty stage 2 of 4	Mammary gland development puberty stage 2 of 4	2	0.049909	2

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	COPI-independent Golgi-to-ER retrograde traffic	3	0.031433	2
REAC	REAC:R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	3	0.039090	2

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0400242	Rectum; peripheral nerve/ganglion[≥Medium]	Rectum; peripheral nerve/ganglion[≥Medium]	4	0.045289	2

Community 3

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-9755779	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	7	5.369693e-15	3
REAC	REAC:R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	1.162230e-14	3
REAC	REAC:R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	4.349346e-14	3
REAC	REAC:R-HSA-111447	Activation of BAD and translocation to mitochondria	Activation of BAD and translocation to mitochondria	7	4.349346e-14	3
REAC	REAC:R-HSA-114452	Activation of BH3-only proteins	Activation of BH3-only proteins	7	1.354759e-11	3
REAC	REAC:R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	Translocation of SLC2A4 (GLUT4) to the plasma membrane	8	9.060760e-11	3
REAC	REAC:R-HSA-69473	G2/M DNA damage checkpoint	G2/M DNA damage checkpoint	8	8.247816e-10	3
REAC	REAC:R-HSA-109606	Intrinsic Pathway for Apoptosis	Intrinsic Pathway for Apoptosis	7	1.149572e-09	3
REAC	REAC:R-HSA-69481	G2/M Checkpoints	G2/M Checkpoints	9	1.703533e-09	3
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	9	2.740973e-09	3
REAC	REAC:R-HSA-9614399	Regulation of localization of FOXO transcription factors	Regulation of localization of FOXO transcription factors	5	3.084518e-09	3
REAC	REAC:R-HSA-69620	Cell Cycle Checkpoints	Cell Cycle Checkpoints	10	6.665138e-09	3
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	9	1.236684e-08	3
REAC	REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	TP53 Regulates Metabolic Genes	7	2.849813e-08	3
REAC	REAC:R-HSA-5625740	RHO GTPases activate PKNs	RHO GTPases activate PKNs	7	5.905122e-08	3
REAC	REAC:R-HSA-9692914	SARS-CoV-1-host interactions	SARS-CoV-1-host interactions	7	6.873445e-08	3
REAC	REAC:R-HSA-195258	RHO GTPase Effectors	RHO GTPase Effectors	9	5.423579e-07	3
REAC	REAC:R-HSA-9678108	SARS-CoV-1 Infection	SARS-CoV-1 Infection	7	1.065931e-06	3
REAC	REAC:R-HSA-9705683	SARS-CoV-2-host interactions	SARS-CoV-2-host interactions	7	1.147028e-05	3
REAC	REAC:R-HSA-199991	Membrane Trafficking	Membrane Trafficking	10	1.217904e-05	3
REAC	REAC:R-HSA-1640170	Cell Cycle	Cell Cycle	10	2.676877e-05	3
REAC	REAC:R-HSA-9614085	FOXO-mediated transcription	FOXO-mediated transcription	5	3.272973e-05	3
REAC	REAC:R-HSA-3700989	Transcriptional Regulation by TP53	Transcriptional Regulation by TP53	8	3.609918e-05	3
REAC	REAC:R-HSA-194315	Signaling by Rho GTPases	Signaling by Rho GTPases	10	3.619836e-05	3
REAC	REAC:R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	10	4.421178e-05	3
REAC	REAC:R-HSA-5653656	Vesicle-mediated transport	Vesicle-mediated transport	10	4.599098e-05	3
REAC	REAC:R-HSA-9694516	SARS-CoV-2 Infection	SARS-CoV-2 Infection	7	1.690370e-04	3
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	9	3.064645e-03	3
REAC	REAC:R-HSA-9679506	SARS-CoV Infections	SARS-CoV Infections	7	3.448592e-03	3
REAC	REAC:R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	Regulation of mRNA stability by proteins that bind AU-rich elements	4	5.208914e-03	3
REAC	REAC:R-HSA-212436	Generic Transcription Pathway	Generic Transcription Pathway	10	6.612113e-03	3
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	9	1.500154e-02	3
REAC	REAC:R-HSA-73857	RNA Polymerase II Transcription	RNA Polymerase II Transcription	10	1.513155e-02	3
REAC	REAC:R-HSA-170984	ARMS-mediated activation	ARMS-mediated activation	2	2.229587e-02	3
REAC	REAC:R-HSA-74160	Gene expression (Transcription)	Gene expression (Transcription)	10	4.066155e-02	3

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5376	17p13 3 YWHAE copy number variation	17p13 3 YWHAE copy number variation	6	1.440844e-10	3
WP	WP:WP179	Cell cycle	Cell cycle	7	1.802105e-07	3
WP	WP:WP536	Calcium regulation in cardiac cells	Calcium regulation in cardiac cells	7	8.643246e-07	3
WP	WP:WP289	Myometrial relaxation and contraction pathways	Myometrial relaxation and contraction pathways	7	1.038839e-06	3
WP	WP:WP706	Sudden infant death syndrome SIDS susceptibility pathways	Sudden infant death syndrome SIDS susceptibility pathways	6	4.662715e-05	3

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:5199	Kinase maturation complex 1	Kinase maturation complex 1	6	1.196871e-08	3

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0050815	phosphoserine residue binding	"Binding to a phosphorylated serine residue within a protein." [GOC:ai]	4	5.732717e-08	3
GO:MF	GO:0045309	protein phosphorylated amino acid binding	"Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators]	5	1.112114e-06	3
GO:MF	GO:0140311	protein sequestering activity	"Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:1493333]	4	7.381287e-06	3
GO:MF	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	5	1.128866e-05	3
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	8	5.165717e-05	3
GO:MF	GO:0140313	molecular sequestering activity	"Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:13130076]	4	6.636453e-05	3
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	6	2.767713e-04	3
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	11	6.336688e-04	3
GO:MF	GO:0008426	protein kinase C inhibitor activity	"Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai]	2	9.846619e-04	3
GO:MF	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	4	4.169121e-03	3
GO:MF	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	6	5.539392e-03	3
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	10	7.625329e-03	3
GO:MF	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	7	1.421408e-02	3
GO:MF	GO:0004860	protein kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a protein kinase." [GOC:ai]	3	1.983824e-02	3
GO:MF	GO:0019210	kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah]	3	2.405752e-02	3
GO:MF	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	4	3.152303e-02	3
GO:MF	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	6	3.540993e-02	3
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	6	3.796201e-02	3
GO:MF	GO:0005159	insulin-like growth factor receptor binding	"Binding to an insulin-like growth factor receptor." [GOC:jl]	2	3.906739e-02	3
GO:MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	7	3.971328e-02	3

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	19	7.572510e-08	3
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	8	5.046917e-07	3
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	8	6.053458e-07	3
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	9	1.083065e-05	3
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	11	1.443529e-04	3
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	11	1.663890e-04	3
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	11	1.671724e-04	3
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	11	1.671724e-04	3
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	13	1.957979e-03	3
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	11	1.196566e-02	3
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	20	1.902182e-02	3
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	12	2.277534e-02	3
GO:CC	GO:0042470	melanosome	"A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]	3	2.906121e-02	3
GO:CC	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	3	2.906121e-02	3
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	9	3.116985e-02	3

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04110	Cell cycle	Cell cycle	7	4.062441e-07	3
KEGG	KEGG:04114	Oocyte meiosis	Oocyte meiosis	6	5.354763e-06	3
KEGG	KEGG:04390	Hippo signaling pathway	Hippo signaling pathway	6	1.575476e-05	3
KEGG	KEGG:05160	Hepatitis C	Hepatitis C	6	1.635990e-05	3
KEGG	KEGG:05203	Viral carcinogenesis	Viral carcinogenesis	6	6.774259e-05	3
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	7	1.118446e-04	3

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	11	0.000487	3
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	12	0.001942	3
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	12	0.002036	3
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	13	0.004871	3
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	9	0.006018	3
GO:BP	GO:0046822	regulation of nucleocytoplasmic transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]	4	0.006419	3
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	10	0.008228	3
GO:BP	GO:0046825	regulation of protein export from nucleus	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf]	3	0.008307	3
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	12	0.010169	3
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	"Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]	3	0.012365	3
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	"Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]	5	0.016652	3
GO:BP	GO:0021762	substantia nigra development	"The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420]	3	0.018741	3
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	7	0.020726	3
GO:BP	GO:0051168	nuclear export	"The directed movement of substances out of the nucleus." [GOC:ai]	4	0.028466	3
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	7	0.042449	3
GO:BP	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	3	0.043315	3

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-193b-3p	hsa-mir-193b-3p	hsa-mir-193b-3p	8	0.001186	3
MIRNA	MIRNA:hsa-let-7e-5p	hsa-let-7e-5p	hsa-let-7e-5p	6	0.020923	3
MIRNA	MIRNA:hsa-mir-5087	hsa-mir-5087	hsa-mir-5087	3	0.033137	3
MIRNA	MIRNA:hsa-mir-320d	hsa-mir-320d	hsa-mir-320d	8	0.043420	3
MIRNA	MIRNA:hsa-mir-4429	hsa-mir-4429	hsa-mir-4429	8	0.043658	3
MIRNA	MIRNA:hsa-mir-320c	hsa-mir-320c	hsa-mir-320c	8	0.048143	3

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0461462	Skin 1; langerhans cells[≥Medium]	Skin 1; langerhans cells[≥Medium]	7	0.002044	3
HPA	HPA:0461463	Skin 1; langerhans cells[High]	Skin 1; langerhans cells[High]	5	0.002352	3
HPA	HPA:0471462	Skin 2; langerhans cells[≥Medium]	Skin 2; langerhans cells[≥Medium]	7	0.004959	3
HPA	HPA:0471463	Skin 2; langerhans cells[High]	Skin 2; langerhans cells[High]	5	0.006137	3
HPA	HPA:0471473	Skin 2; lymphocytes[High]	Skin 2; lymphocytes[High]	6	0.006425	3
HPA	HPA:0461461	Skin 1; langerhans cells[≥Low]	Skin 1; langerhans cells[≥Low]	7	0.008234	3
HPA	HPA:0100122	Cerebral cortex; glial cells[≥Medium]	Cerebral cortex; glial cells[≥Medium]	12	0.011896	3
HPA	HPA:0471461	Skin 2; langerhans cells[≥Low]	Skin 2; langerhans cells[≥Low]	7	0.015338	3
HPA	HPA:0050012	Breast; adipocytes[≥Medium]	Breast; adipocytes[≥Medium]	9	0.020565	3
HPA	HPA:0461472	Skin 1; lymphocytes[≥Medium]	Skin 1; lymphocytes[≥Medium]	6	0.023471	3
HPA	HPA:0461473	Skin 1; lymphocytes[High]	Skin 1; lymphocytes[High]	5	0.039352	3
HPA	HPA:0100121	Cerebral cortex; glial cells[≥Low]	Cerebral cortex; glial cells[≥Low]	15	0.041322	3
HPA	HPA:0470672	Skin 2; melanocytes[≥Medium]	Skin 2; melanocytes[≥Medium]	6	0.042275	3
HPA	HPA:0600222	Tonsil; squamous epithelial cells[≥Medium]	Tonsil; squamous epithelial cells[≥Medium]	15	0.043423	3
HPA	HPA:0471472	Skin 2; lymphocytes[≥Medium]	Skin 2; lymphocytes[≥Medium]	6	0.044861	3

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M09826	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC	Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC	21	0.037249	3
TF	TF:M01118	Factor: WT1; motif: SMCNCCNSC	Factor: WT1; motif: SMCNCCNSC	17	0.042047	3

Community 4

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0034452	dynactin binding	"Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah]	3	0.000029	4
GO:MF	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	3	0.000430	4
GO:MF	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	3	0.001015	4
GO:MF	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	6	0.030063	4
GO:MF	GO:0008093	cytoskeletal anchor activity	"The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238]	2	0.048967	4

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0072393	microtubule anchoring at microtubule organizing center	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938]	3	0.000182	4
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	11	0.000652	4
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	11	0.000682	4
GO:BP	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	3	0.001292	4
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	11	0.003141	4
GO:BP	GO:0072385	minus-end-directed organelle transport along microtubule	"The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah]	2	0.004520	4
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	11	0.011255	4
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	4	0.021834	4
GO:BP	GO:0051656	establishment of organelle localization	"The directed movement of an organelle to a specific location." [GOC:ai]	5	0.033359	4

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	9	0.004071	4
GO:CC	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	7	0.007526	4
GO:CC	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	5	0.027448	4
GO:CC	GO:0099513	polymeric cytoskeletal fiber	"A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]	5	0.043104	4

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP4352	Ciliary landscape	Ciliary landscape	4	0.008782	4

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-4316	hsa-mir-4316	hsa-mir-4316	7	0.013224	4
MIRNA	MIRNA:hsa-mir-200a	hsa-mir-200a	hsa-mir-200a	8	0.028469	4
MIRNA	MIRNA:hsa-mir-141	hsa-mir-141	hsa-mir-141	8	0.028469	4

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response	3	0.019180	4
REAC	REAC:R-HSA-3371556	Cellular response to heat stress	Cellular response to heat stress	3	0.041861	4

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:1530	Girdin homo-oligomer complex	Girdin homo-oligomer complex	1	0.049819	4

washu+biogrid+hippie (Leiden)

View:

washu+biogrid+hippie (Louvain)

View:

Community 0

GO:CC

source	term_id	annotation	description	intersection_size	p_value
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	45	0.000261
GO:CC	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]	13	0.002155
GO:CC	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	4	0.002449
GO:CC	GO:0036477	somatodendritic compartment	"The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]	10	0.005643
GO:CC	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	4	0.006125
GO:CC	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	16	0.010295
GO:CC	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]	16	0.018822
GO:CC	GO:0072357	PTW/PP1 phosphatase complex	"A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061]	2	0.027502
GO:CC	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	7	0.035641
GO:CC	GO:0030991	intraciliary transport particle A	"The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]	2	0.036616
GO:CC	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	4	0.040015
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	25	0.045292

KEGG

source	term_id	annotation	description	intersection_size	p_value
KEGG	KEGG:04931	Insulin resistance	Insulin resistance	5	0.000866
KEGG	KEGG:05415	Diabetic cardiomyopathy	Diabetic cardiomyopathy	6	0.001345
KEGG	KEGG:04910	Insulin signaling pathway	Insulin signaling pathway	5	0.002740

GO:BP

source	term_id	annotation	description	intersection_size	p_value
GO:BP	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	5	0.002497
GO:BP	GO:0044042	glucan metabolic process	"The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl]	5	0.002807
GO:BP	GO:1990535	neuron projection maintenance	"The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:kmv, PMID:25359212]	3	0.004297
GO:BP	GO:0006112	energy reserve metabolic process	"The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah]	5	0.005361
GO:BP	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	18	0.006172
GO:BP	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	18	0.006283
GO:BP	GO:0005976	polysaccharide metabolic process	"The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684]	5	0.006529
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	13	0.018857
GO:BP	GO:0006091	generation of precursor metabolites and energy	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]	8	0.022309
GO:BP	GO:0043153	entrainment of circadian clock by photoperiod	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]	3	0.038763
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	21	0.046314

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP4861	Endoplasmic reticulum stress response in coronavirus infection	Endoplasmic reticulum stress response in coronavirus infection	4	0.002556	0

REAC

source	term_id	annotation	description	intersection_size	p_value
REAC	REAC:R-HSA-9828806	Maturation of hRSV A proteins	Maturation of hRSV A proteins	3	0.002806
REAC	REAC:R-HSA-9820965	Respiratory syncytial virus (RSV) genome replication, transcription and translation	Respiratory syncytial virus (RSV) genome replication, transcription and translation	3	0.005458
REAC	REAC:R-HSA-2173788	Downregulation of TGF-beta receptor signaling	Downregulation of TGF-beta receptor signaling	3	0.021981

TF

source	term_id	annotation	description	intersection_size	p_value
TF	TF:M09894_1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1	51	0.010850
TF	TF:M00716_1	Factor: ZF5; motif: GSGCGCGR; match class: 1	Factor: ZF5; motif: GSGCGCGR; match class: 1	51	0.018176
TF	TF:M12158_1	Factor: KLF15; motif: NCCMCGCCCMCN; match class: 1	Factor: KLF15; motif: NCCMCGCCCMCN; match class: 1	30	0.018934
TF	TF:M12153	Factor: Sp3; motif: NGCCACGCCCMCN	Factor: Sp3; motif: NGCCACGCCCMCN	32	0.040452

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:1903135	cupric ion binding	"Binding to a cupric ion, copper(2+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]	2	0.019945	0

Community 1

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response	6	0.000004	1
REAC	REAC:R-HSA-3371556	Cellular response to heat stress	Cellular response to heat stress	6	0.000017	1
REAC	REAC:R-HSA-2262752	Cellular responses to stress	Cellular responses to stress	11	0.000385	1
REAC	REAC:R-HSA-8953897	Cellular responses to stimuli	Cellular responses to stimuli	11	0.000458	1
REAC	REAC:R-HSA-3371511	HSF1 activation	HSF1 activation	3	0.000933	1
REAC	REAC:R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	3	0.001539	1
REAC	REAC:R-HSA-69166	Removal of the Flap Intermediate	Removal of the Flap Intermediate	3	0.001539	1
REAC	REAC:R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	3	0.001539	1
REAC	REAC:R-HSA-69183	Processive synthesis on the lagging strand	Processive synthesis on the lagging strand	3	0.001921	1
REAC	REAC:R-HSA-5358508	Mismatch Repair	Mismatch Repair	3	0.001921	1
REAC	REAC:R-HSA-110312	Translesion synthesis by REV1	Translesion synthesis by REV1	3	0.002360	1
REAC	REAC:R-HSA-174437	Removal of the Flap Intermediate from the C-strand	Removal of the Flap Intermediate from the C-strand	3	0.002861	1
REAC	REAC:R-HSA-5656121	Translesion synthesis by POLI	Translesion synthesis by POLI	3	0.002861	1
REAC	REAC:R-HSA-5655862	Translesion synthesis by POLK	Translesion synthesis by POLK	3	0.002861	1
REAC	REAC:R-HSA-69239	Synthesis of DNA	Synthesis of DNA	5	0.003216	1
REAC	REAC:R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	4	0.003395	1
REAC	REAC:R-HSA-174414	Processive synthesis on the C-strand of the telomere	Processive synthesis on the C-strand of the telomere	3	0.004064	1
REAC	REAC:R-HSA-110320	Translesion Synthesis by POLH	Translesion Synthesis by POLH	3	0.004064	1
REAC	REAC:R-HSA-69206	G1/S Transition	G1/S Transition	5	0.004735	1
REAC	REAC:R-HSA-69186	Lagging Strand Synthesis	Lagging Strand Synthesis	3	0.004774	1
REAC	REAC:R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	PCNA-Dependent Long Patch Base Excision Repair	3	0.005560	1
REAC	REAC:R-HSA-453279	Mitotic G1 phase and G1/S transition	Mitotic G1 phase and G1/S transition	5	0.008547	1
REAC	REAC:R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	Gap-filling DNA repair synthesis and ligation in GG-NER	3	0.009552	1
REAC	REAC:R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	3	0.009552	1
REAC	REAC:R-HSA-69278	Cell Cycle, Mitotic	Cell Cycle, Mitotic	8	0.011388	1
REAC	REAC:R-HSA-69002	DNA Replication Pre-Initiation	DNA Replication Pre-Initiation	5	0.012066	1
REAC	REAC:R-HSA-69242	S Phase	S Phase	5	0.013197	1
REAC	REAC:R-HSA-69481	G2/M Checkpoints	G2/M Checkpoints	5	0.015263	1
REAC	REAC:R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	Recognition of DNA damage by PCNA-containing replication complex	3	0.016725	1
REAC	REAC:R-HSA-69620	Cell Cycle Checkpoints	Cell Cycle Checkpoints	6	0.018923	1
REAC	REAC:R-HSA-69190	DNA strand elongation	DNA strand elongation	3	0.020365	1
REAC	REAC:R-HSA-5656169	Termination of translesion DNA synthesis	Termination of translesion DNA synthesis	3	0.020365	1
REAC	REAC:R-HSA-68962	Activation of the pre-replicative complex	Activation of the pre-replicative complex	3	0.022365	1
REAC	REAC:R-HSA-4086400	PCP/CE pathway	PCP/CE pathway	4	0.022649	1
REAC	REAC:R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	Telomere C-strand (Lagging Strand) Synthesis	3	0.024489	1
REAC	REAC:R-HSA-69306	DNA Replication	DNA Replication	5	0.026155	1
REAC	REAC:R-HSA-9709570	Impaired BRCA2 binding to RAD51	Impaired BRCA2 binding to RAD51	3	0.026742	1
REAC	REAC:R-HSA-73933	Resolution of Abasic Sites (AP sites)	Resolution of Abasic Sites (AP sites)	3	0.029125	1
REAC	REAC:R-HSA-5685938	HDR through Single Strand Annealing (SSA)	HDR through Single Strand Annealing (SSA)	3	0.031643	1
REAC	REAC:R-HSA-176187	Activation of ATR in response to replication stress	Activation of ATR in response to replication stress	3	0.031643	1
REAC	REAC:R-HSA-6807878	COPI-mediated anterograde transport	COPI-mediated anterograde transport	4	0.033875	1
REAC	REAC:R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	3	0.037097	1
REAC	REAC:R-HSA-6783310	Fanconi Anemia Pathway	Fanconi Anemia Pathway	3	0.037097	1
REAC	REAC:R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	Presynaptic phase of homologous DNA pairing and strand exchange	3	0.040039	1
REAC	REAC:R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	Diseases of DNA Double-Strand Break Repair	3	0.043129	1
REAC	REAC:R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	3	0.043129	1
REAC	REAC:R-HSA-5696400	Dual Incision in GG-NER	Dual Incision in GG-NER	3	0.043129	1
REAC	REAC:R-HSA-5696395	Formation of Incision Complex in GG-NER	Formation of Incision Complex in GG-NER	3	0.049768	1
REAC	REAC:R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	Homologous DNA Pairing and Strand Exchange	3	0.049768	1

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	24	0.000016	1
GO:CC	GO:0005662	DNA replication factor A complex	"A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]	3	0.000233	1
GO:CC	GO:0043601	nuclear replisome	"A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]	3	0.001245	1
GO:CC	GO:0030894	replisome	"A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]	3	0.001633	1
GO:CC	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	3	0.008442	1
GO:CC	GO:1904813	ficolin-1-rich granule lumen	"Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620]	4	0.009780	1
GO:CC	GO:0034774	secretory granule lumen	"The volume enclosed by the membrane of a secretory granule." [GOC:rph]	5	0.033091	1
GO:CC	GO:0060205	cytoplasmic vesicle lumen	"The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles]	5	0.035548	1
GO:CC	GO:0031983	vesicle lumen	"The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles]	5	0.036056	1
GO:CC	GO:0101002	ficolin-1-rich granule	"Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154]	4	0.045054	1
GO:CC	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	34	0.049807	1

HPA

source	term_id	annotation	description	intersection_size	p_value	community
HPA	HPA:0160251	Endometrium 1; cells in endometrial stroma[≥Low]	Endometrium 1; cells in endometrial stroma[≥Low]	24	0.000113	1
HPA	HPA:0050092	Breast; myoepithelial cells[≥Medium]	Breast; myoepithelial cells[≥Medium]	22	0.001096	1
HPA	HPA:0510000	Soft tissue 2	Soft tissue 2	25	0.002932	1
HPA	HPA:0040081	Bone marrow; hematopoietic cells[≥Low]	Bone marrow; hematopoietic cells[≥Low]	27	0.009356	1
HPA	HPA:0040000	Bone marrow	Bone marrow	27	0.009356	1
HPA	HPA:0250131	Hippocampus; neuronal cells[≥Low]	Hippocampus; neuronal cells[≥Low]	26	0.023896	1
HPA	HPA:0050011	Breast; adipocytes[≥Low]	Breast; adipocytes[≥Low]	17	0.026487	1
HPA	HPA:0510651	Soft tissue 2; fibroblasts[≥Low]	Soft tissue 2; fibroblasts[≥Low]	21	0.027129	1
HPA	HPA:0100121	Cerebral cortex; glial cells[≥Low]	Cerebral cortex; glial cells[≥Low]	23	0.029498	1
HPA	HPA:0040083	Bone marrow; hematopoietic cells[High]	Bone marrow; hematopoietic cells[High]	12	0.031649	1
HPA	HPA:0380521	Placenta; trophoblastic cells[≥Low]	Placenta; trophoblastic cells[≥Low]	26	0.038545	1
HPA	HPA:0170251	Endometrium 2; cells in endometrial stroma[≥Low]	Endometrium 2; cells in endometrial stroma[≥Low]	19	0.040462	1
HPA	HPA:0500651	Soft tissue 1; fibroblasts[≥Low]	Soft tissue 1; fibroblasts[≥Low]	21	0.041801	1
HPA	HPA:0380000	Placenta	Placenta	28	0.042196	1
HPA	HPA:0170000	Endometrium 2	Endometrium 2	27	0.042451	1
HPA	HPA:0490000	Smooth muscle	Smooth muscle	24	0.042563	1
HPA	HPA:0490691	Smooth muscle; smooth muscle cells[≥Low]	Smooth muscle; smooth muscle cells[≥Low]	24	0.042563	1
HPA	HPA:0630221	Cervix; squamous epithelial cells[≥Low]	Cervix; squamous epithelial cells[≥Low]	24	0.043335	1
HPA	HPA:0100201	Cerebral cortex; endothelial cells[≥Low]	Cerebral cortex; endothelial cells[≥Low]	22	0.044278	1

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP3875	ATR signaling	ATR signaling	3	0.000425	1
WP	WP:WP531	DNA mismatch repair	DNA mismatch repair	3	0.004461	1
WP	WP:WP466	DNA replication	DNA replication	3	0.027943	1
WP	WP:WP4753	Nucleotide excision repair	Nucleotide excision repair	3	0.029985	1
WP	WP:WP4352	Ciliary landscape	Ciliary landscape	5	0.035717	1

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:03430	Mismatch repair	Mismatch repair	3	0.002523	1
KEGG	KEGG:03030	DNA replication	DNA replication	3	0.009919	1
KEGG	KEGG:03440	Homologous recombination	Homologous recombination	3	0.014666	1
KEGG	KEGG:03460	Fanconi anemia pathway	Fanconi anemia pathway	3	0.033274	1
KEGG	KEGG:03420	Nucleotide excision repair	Nucleotide excision repair	3	0.047627	1

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-let-7b-5p	hsa-let-7b-5p	hsa-let-7b-5p	11	0.006460	1
MIRNA	MIRNA:hsa-mir-3147	hsa-mir-3147	hsa-mir-3147	8	0.019937	1
MIRNA	MIRNA:hsa-mir-6514-5p	hsa-mir-6514-5p	hsa-mir-6514-5p	4	0.027807	1

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:5229	RPA complex	RPA complex	2	0.016716	1

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	6	0.020776	1
GO:BP	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	3	0.029201	1
GO:BP	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	7	0.030293	1
GO:BP	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	9	0.035933	1
GO:BP	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	8	0.038371	1
GO:BP	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	5	0.042107	1

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0098505	G-rich strand telomeric DNA binding	"Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150]	2	0.049654	1

Community 2

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-9755779	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	7	4.454691e-14	2
REAC	REAC:R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	9.637235e-14	2
REAC	REAC:R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	3.603040e-13	2
REAC	REAC:R-HSA-111447	Activation of BAD and translocation to mitochondria	Activation of BAD and translocation to mitochondria	7	3.603040e-13	2
REAC	REAC:R-HSA-114452	Activation of BH3-only proteins	Activation of BH3-only proteins	7	1.114273e-10	2
REAC	REAC:R-HSA-109581	Apoptosis	Apoptosis	10	1.203373e-09	2
REAC	REAC:R-HSA-9705683	SARS-CoV-2-host interactions	SARS-CoV-2-host interactions	10	3.715033e-09	2
REAC	REAC:R-HSA-5357801	Programmed Cell Death	Programmed Cell Death	10	6.381710e-09	2
REAC	REAC:R-HSA-109606	Intrinsic Pathway for Apoptosis	Intrinsic Pathway for Apoptosis	7	9.347085e-09	2
REAC	REAC:R-HSA-9614399	Regulation of localization of FOXO transcription factors	Regulation of localization of FOXO transcription factors	5	1.278438e-08	2
REAC	REAC:R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	Translocation of SLC2A4 (GLUT4) to the plasma membrane	7	7.565317e-08	2
REAC	REAC:R-HSA-9694516	SARS-CoV-2 Infection	SARS-CoV-2 Infection	10	1.806106e-07	2
REAC	REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	TP53 Regulates Metabolic Genes	7	2.284090e-07	2
REAC	REAC:R-HSA-9678108	SARS-CoV-1 Infection	SARS-CoV-1 Infection	8	2.410374e-07	2
REAC	REAC:R-HSA-5625740	RHO GTPases activate PKNs	RHO GTPases activate PKNs	7	4.712500e-07	2
REAC	REAC:R-HSA-69473	G2/M DNA damage checkpoint	G2/M DNA damage checkpoint	7	5.083932e-07	2
REAC	REAC:R-HSA-9692914	SARS-CoV-1-host interactions	SARS-CoV-1-host interactions	7	5.479997e-07	2
REAC	REAC:R-HSA-9679506	SARS-CoV Infections	SARS-CoV Infections	10	1.403569e-05	2
REAC	REAC:R-HSA-199991	Membrane Trafficking	Membrane Trafficking	11	2.140832e-05	2
REAC	REAC:R-HSA-69481	G2/M Checkpoints	G2/M Checkpoints	7	2.812073e-05	2
REAC	REAC:R-HSA-5653656	Vesicle-mediated transport	Vesicle-mediated transport	11	8.937980e-05	2
REAC	REAC:R-HSA-9614085	FOXO-mediated transcription	FOXO-mediated transcription	5	1.323609e-04	2
REAC	REAC:R-HSA-195258	RHO GTPase Effectors	RHO GTPase Effectors	8	1.473119e-04	2
REAC	REAC:R-HSA-194315	Signaling by Rho GTPases	Signaling by Rho GTPases	10	7.180032e-04	2
REAC	REAC:R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	10	8.701452e-04	2
REAC	REAC:R-HSA-69620	Cell Cycle Checkpoints	Cell Cycle Checkpoints	7	1.144661e-03	2
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	11	4.226774e-03	2
REAC	REAC:R-HSA-3700989	Transcriptional Regulation by TP53	Transcriptional Regulation by TP53	7	4.758612e-03	2
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	10	5.128369e-03	2
REAC	REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	Apoptotic cleavage of cellular proteins	3	2.875621e-02	2

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5376	17p13 3 YWHAE copy number variation	17p13 3 YWHAE copy number variation	6	8.646404e-10	2
WP	WP:WP179	Cell cycle	Cell cycle	7	1.497120e-06	2
WP	WP:WP536	Calcium regulation in cardiac cells	Calcium regulation in cardiac cells	7	7.072552e-06	2
WP	WP:WP289	Myometrial relaxation and contraction pathways	Myometrial relaxation and contraction pathways	7	8.483392e-06	2
WP	WP:WP706	Sudden infant death syndrome SIDS susceptibility pathways	Sudden infant death syndrome SIDS susceptibility pathways	6	2.614231e-04	2
WP	WP:WP2272	Pathogenic Escherichia coli infection	Pathogenic Escherichia coli infection	3	4.527815e-02	2

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:5199	Kinase maturation complex 1	Kinase maturation complex 1	6	4.347736e-08	2

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	24	2.705011e-07	2
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	20	3.359973e-06	2
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	31	4.301631e-06	2
GO:CC	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	8	1.931676e-05	2
GO:CC	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	8	2.307548e-05	2
GO:CC	GO:0070161	anchoring junction	"A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]	10	5.531844e-05	2
GO:CC	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	13	4.216028e-04	2
GO:CC	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	13	4.944362e-04	2
GO:CC	GO:0065010	extracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]	13	4.970471e-04	2
GO:CC	GO:0043230	extracellular organelle	"Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]	13	4.970471e-04	2
GO:CC	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	14	1.199927e-02	2
GO:CC	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	12	1.384480e-02	2
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	12	1.907985e-02	2
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	12	1.952303e-02	2
GO:CC	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	15	4.723588e-02	2

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0050815	phosphoserine residue binding	"Binding to a phosphorylated serine residue within a protein." [GOC:ai]	4	3.782651e-07	2
GO:MF	GO:0140311	protein sequestering activity	"Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:1493333]	4	4.832076e-05	2
GO:MF	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	5	1.143617e-04	2
GO:MF	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	9	1.578423e-04	2
GO:MF	GO:0140313	molecular sequestering activity	"Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active." [PMID:13130076]	4	4.308581e-04	2
GO:MF	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	14	4.935066e-04	2
GO:MF	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	6	6.037863e-04	2
GO:MF	GO:0045309	protein phosphorylated amino acid binding	"Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators]	4	7.780203e-04	2
GO:MF	GO:0019207	kinase regulator activity	"Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]	6	1.412787e-03	2
GO:MF	GO:0004860	protein kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a protein kinase." [GOC:ai]	4	2.042581e-03	2
GO:MF	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	13	2.211520e-03	2
GO:MF	GO:0019210	kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah]	4	2.643721e-03	2
GO:MF	GO:0008426	protein kinase C inhibitor activity	"Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai]	2	2.742083e-03	2
GO:MF	GO:0070840	dynein complex binding	"Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]	3	2.946388e-03	2
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	8	3.671899e-03	2
GO:MF	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	6	4.108951e-03	2
GO:MF	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	9	5.122467e-03	2
GO:MF	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	8	7.838778e-03	2
GO:MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	9	1.852920e-02	2
GO:MF	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	4	2.610276e-02	2

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04110	Cell cycle	Cell cycle	7	0.000003	2
KEGG	KEGG:04390	Hippo signaling pathway	Hippo signaling pathway	7	0.000003	2
KEGG	KEGG:05160	Hepatitis C	Hepatitis C	7	0.000003	2
KEGG	KEGG:05203	Viral carcinogenesis	Viral carcinogenesis	7	0.000014	2
KEGG	KEGG:04114	Oocyte meiosis	Oocyte meiosis	6	0.000025	2
KEGG	KEGG:04151	PI3K-Akt signaling pathway	PI3K-Akt signaling pathway	7	0.000659	2
KEGG	KEGG:05161	Hepatitis B	Hepatitis B	4	0.030898	2

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	16	0.000174	2
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	18	0.000180	2
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	16	0.000185	2
GO:BP	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	14	0.000199	2
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	"Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]	7	0.000378	2
GO:BP	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	15	0.000596	2
GO:BP	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	10	0.000997	2
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	13	0.001494	2
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	16	0.001495	2
GO:BP	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	19	0.001548	2
GO:BP	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	12	0.002926	2
GO:BP	GO:0051234	establishment of localization	"Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]	19	0.003049	2
GO:BP	GO:0034762	regulation of transmembrane transport	"Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]	7	0.003280	2
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	20	0.003587	2
GO:BP	GO:0043269	regulation of monoatomic ion transport	"Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	7	0.003748	2
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	"Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]	6	0.003763	2
GO:BP	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	9	0.004076	2
GO:BP	GO:0048857	neural nucleus development	"The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021]	4	0.004486	2
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	12	0.007527	2
GO:BP	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	11	0.008539	2
GO:BP	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	20	0.013055	2
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	10	0.016312	2
GO:BP	GO:0010959	regulation of metal ion transport	"Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	6	0.018258	2
GO:BP	GO:0072385	minus-end-directed organelle transport along microtubule	"The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah]	2	0.019646	2
GO:BP	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	15	0.024764	2
GO:BP	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	15	0.025485	2
GO:BP	GO:0043412	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	14	0.026291	2
GO:BP	GO:0043271	negative regulation of monoatomic ion transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	4	0.030238	2
GO:BP	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	14	0.032452	2
GO:BP	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	16	0.032586	2
GO:BP	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	10	0.032940	2
GO:BP	GO:0046822	regulation of nucleocytoplasmic transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]	4	0.033530	2
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	"Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]	3	0.043348	2
GO:BP	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	9	0.047033	2

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M11601_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	31	0.000723	2
TF	TF:M12351_1	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1	Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1	27	0.001656	2
TF	TF:M05499	Factor: LKLF; motif: NGGGCGG	Factor: LKLF; motif: NGGGCGG	26	0.006030	2
TF	TF:M05386	Factor: KLF17; motif: NGGGCGG	Factor: KLF17; motif: NGGGCGG	26	0.006030	2
TF	TF:M11603_1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1	32	0.007066	2
TF	TF:M00196_1	Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1	Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1	22	0.020051	2
TF	TF:M07040	Factor: GKLF; motif: NNRRGRRNGNSNNN	Factor: GKLF; motif: NNRRGRRNGNSNNN	31	0.037796	2

MIRNA

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-4643	hsa-mir-4643	hsa-mir-4643	13	0.000887	2
MIRNA	MIRNA:hsa-mir-3692	hsa-mir-3692	hsa-mir-3692	11	0.006882	2
MIRNA	MIRNA:hsa-mir-4760-3p	hsa-mir-4760-3p	hsa-mir-4760-3p	11	0.007303	2
MIRNA	MIRNA:hsa-mir-4272	hsa-mir-4272	hsa-mir-4272	10	0.015283	2
MIRNA	MIRNA:hsa-mir-653	hsa-mir-653	hsa-mir-653	8	0.017814	2

Community 3

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0030125	clathrin vesicle coat	"A clathrin coat found on a vesicle." [GOC:mah]	11	1.271751e-23	3
GO:CC	GO:0005905	clathrin-coated pit	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]	12	6.449897e-22	3
GO:CC	GO:0030118	clathrin coat	"A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]	11	1.439227e-21	3
GO:CC	GO:0030132	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	9	6.617303e-21	3
GO:CC	GO:0030120	vesicle coat	"A membrane coat found on a coated vesicle." [GOC:mah]	11	1.848872e-20	3
GO:CC	GO:0030136	clathrin-coated vesicle	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]	14	2.094092e-20	3
GO:CC	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	11	3.711746e-18	3
GO:CC	GO:0048475	coated membrane	"A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid]	11	3.711746e-18	3
GO:CC	GO:0030135	coated vesicle	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]	14	3.983608e-18	3
GO:CC	GO:0030665	clathrin-coated vesicle membrane	"The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah]	11	1.292375e-16	3
GO:CC	GO:0045334	clathrin-coated endocytic vesicle	"A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]	10	2.372523e-16	3
GO:CC	GO:0036020	endolysosome membrane	"The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]	7	9.982192e-15	3
GO:CC	GO:0030662	coated vesicle membrane	"The lipid bilayer surrounding a coated vesicle." [GOC:mah]	11	1.081156e-14	3
GO:CC	GO:0030128	clathrin coat of endocytic vesicle	"A clathrin coat found on an endocytic vesicle." [GOC:mah]	6	7.356975e-14	3
GO:CC	GO:0030122	AP-2 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426]	6	7.356975e-14	3
GO:CC	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	7	1.138140e-13	3
GO:CC	GO:0036019	endolysosome	"An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place." [GOC:pde, PMID:21878991]	7	1.997680e-13	3
GO:CC	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	7	4.085787e-12	3
GO:CC	GO:0030130	clathrin coat of trans-Golgi network vesicle	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]	6	4.296521e-12	3
GO:CC	GO:0012510	trans-Golgi network transport vesicle membrane	"The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai]	6	8.581067e-12	3
GO:CC	GO:0030669	clathrin-coated endocytic vesicle membrane	"The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah]	7	1.831696e-10	3
GO:CC	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	10	2.754870e-10	3
GO:CC	GO:0030140	trans-Golgi network transport vesicle	"A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]	6	5.095003e-10	3
GO:CC	GO:0030660	Golgi-associated vesicle membrane	"The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]	6	6.237503e-09	3
GO:CC	GO:0005798	Golgi-associated vesicle	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]	6	1.391231e-07	3
GO:CC	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	12	2.819491e-07	3
GO:CC	GO:0030666	endocytic vesicle membrane	"The lipid bilayer surrounding an endocytic vesicle." [GOC:mah]	7	3.094080e-07	3
GO:CC	GO:0012506	vesicle membrane	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]	12	3.347110e-07	3
GO:CC	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	12	9.470601e-07	3
GO:CC	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	9	2.322462e-06	3
GO:CC	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	8	2.986075e-06	3
GO:CC	GO:0098852	lytic vacuole membrane	"The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]	8	2.986075e-06	3
GO:CC	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	8	3.090495e-06	3
GO:CC	GO:0005774	vacuolar membrane	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]	8	6.438414e-06	3
GO:CC	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	9	6.719499e-06	3
GO:CC	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	19	7.546703e-06	3
GO:CC	GO:0098835	presynaptic endocytic zone membrane	"The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release." [GOC:dos]	3	7.589746e-06	3
GO:CC	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	14	8.863013e-06	3
GO:CC	GO:0097708	intracellular vesicle	"Any vesicle that is part of the intracellular region." [GOC:vesicles]	14	9.133759e-06	3
GO:CC	GO:0098833	presynaptic endocytic zone	"A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity." [PMID:17455288]	3	1.213496e-05	3
GO:CC	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	13	1.969413e-05	3
GO:CC	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	8	2.138140e-05	3
GO:CC	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	6	2.839779e-05	3
GO:CC	GO:0098843	postsynaptic endocytic zone	"A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins." [PMID:17880892]	3	3.567856e-05	3
GO:CC	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]	13	4.230722e-05	3
GO:CC	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	6	4.613460e-05	3
GO:CC	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	6	4.613460e-05	3
GO:CC	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	11	8.134853e-05	3
GO:CC	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	5	1.592117e-04	3
GO:CC	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	8	1.795169e-04	3
GO:CC	GO:0000323	lytic vacuole	"A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]	8	1.795169e-04	3
GO:CC	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	9	2.019667e-04	3
GO:CC	GO:0099631	postsynaptic endocytic zone cytoplasmic component	"The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos]	2	2.189209e-04	3
GO:CC	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	15	3.747466e-04	3
GO:CC	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	8	4.368384e-04	3
GO:CC	GO:0098562	cytoplasmic side of membrane	"The side of a membrane that faces the cytoplasm." [GOC:dos]	5	5.216279e-04	3
GO:CC	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	16	6.670714e-04	3
GO:CC	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	7	2.584244e-03	3
GO:CC	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	17	4.374693e-03	3
GO:CC	GO:0071439	clathrin complex	"A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411]	2	6.105473e-03	3
GO:CC	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	9	6.565259e-03	3
GO:CC	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	16	8.469444e-03	3
GO:CC	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	13	9.053092e-03	3
GO:CC	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	24	1.077832e-02	3
GO:CC	GO:0030121	AP-1 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]	2	1.695188e-02	3
GO:CC	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	7	2.322968e-02	3
GO:CC	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	20	2.496356e-02	3
GO:CC	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	4	3.580458e-02	3
GO:CC	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	22	4.044402e-02	3
GO:CC	GO:0032588	trans-Golgi network membrane	"The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]	3	4.233960e-02	3

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-5099900	WNT5A-dependent internalization of FZD4	WNT5A-dependent internalization of FZD4	9	7.260291e-20	3
REAC	REAC:R-HSA-8856828	Clathrin-mediated endocytosis	Clathrin-mediated endocytosis	13	1.253954e-17	3
REAC	REAC:R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	8	1.580148e-17	3
REAC	REAC:R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis	12	2.636134e-17	3
REAC	REAC:R-HSA-177504	Retrograde neurotrophin signalling	Retrograde neurotrophin signalling	7	3.301468e-14	3
REAC	REAC:R-HSA-8866427	VLDLR internalisation and degradation	VLDLR internalisation and degradation	7	1.098038e-13	3
REAC	REAC:R-HSA-8964038	LDL clearance	LDL clearance	7	4.820203e-13	3
REAC	REAC:R-HSA-437239	Recycling pathway of L1	Recycling pathway of L1	8	4.465354e-12	3
REAC	REAC:R-HSA-3928665	EPH-ephrin mediated repulsion of cells	EPH-ephrin mediated repulsion of cells	8	5.331019e-12	3
REAC	REAC:R-HSA-4086400	PCP/CE pathway	PCP/CE pathway	9	1.168094e-11	3
REAC	REAC:R-HSA-8964043	Plasma lipoprotein clearance	Plasma lipoprotein clearance	7	7.835465e-11	3
REAC	REAC:R-HSA-199991	Membrane Trafficking	Membrane Trafficking	14	8.179902e-11	3
REAC	REAC:R-HSA-182218	Nef Mediated CD8 Down-regulation	Nef Mediated CD8 Down-regulation	5	1.023694e-10	3
REAC	REAC:R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	6	3.790181e-10	3
REAC	REAC:R-HSA-5653656	Vesicle-mediated transport	Vesicle-mediated transport	14	5.589125e-10	3
REAC	REAC:R-HSA-167590	Nef Mediated CD4 Down-regulation	Nef Mediated CD4 Down-regulation	5	6.127280e-10	3
REAC	REAC:R-HSA-3858494	Beta-catenin independent WNT signaling	Beta-catenin independent WNT signaling	9	6.812982e-10	3
REAC	REAC:R-HSA-2682334	EPH-Ephrin signaling	EPH-Ephrin signaling	8	8.774912e-10	3
REAC	REAC:R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	The role of Nef in HIV-1 replication and disease pathogenesis	6	2.053069e-09	3
REAC	REAC:R-HSA-373760	L1CAM interactions	L1CAM interactions	8	8.609451e-09	3
REAC	REAC:R-HSA-2132295	MHC class II antigen presentation	MHC class II antigen presentation	8	1.125815e-08	3
REAC	REAC:R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	Plasma lipoprotein assembly, remodeling, and clearance	7	1.200394e-08	3
REAC	REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	Signaling by NTRK1 (TRKA)	7	2.931286e-07	3
REAC	REAC:R-HSA-166520	Signaling by NTRKs	Signaling by NTRKs	7	8.924824e-07	3
REAC	REAC:R-HSA-196025	Formation of annular gap junctions	Formation of annular gap junctions	4	1.034430e-06	3
REAC	REAC:R-HSA-195721	Signaling by WNT	Signaling by WNT	9	1.121346e-06	3
REAC	REAC:R-HSA-190873	Gap junction degradation	Gap junction degradation	4	1.549726e-06	3
REAC	REAC:R-HSA-162909	Host Interactions of HIV factors	Host Interactions of HIV factors	6	3.188142e-05	3
REAC	REAC:R-HSA-199992	trans-Golgi Network Vesicle Budding	trans-Golgi Network Vesicle Budding	5	6.757888e-05	3
REAC	REAC:R-HSA-422475	Axon guidance	Axon guidance	9	9.040348e-05	3
REAC	REAC:R-HSA-9675108	Nervous system development	Nervous system development	9	1.325243e-04	3
REAC	REAC:R-HSA-432720	Lysosome Vesicle Biogenesis	Lysosome Vesicle Biogenesis	4	1.790198e-04	3
REAC	REAC:R-HSA-190828	Gap junction trafficking	Gap junction trafficking	4	6.336359e-04	3
REAC	REAC:R-HSA-157858	Gap junction trafficking and regulation	Gap junction trafficking and regulation	4	6.878822e-04	3
REAC	REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	Signaling by Receptor Tyrosine Kinases	8	8.459296e-04	3
REAC	REAC:R-HSA-162906	HIV Infection	HIV Infection	6	9.497159e-04	3
REAC	REAC:R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	Entry of Influenza Virion into Host Cell via Endocytosis	2	1.118989e-03	3
REAC	REAC:R-HSA-9679191	Potential therapeutics for SARS	Potential therapeutics for SARS	5	2.423336e-03	3
REAC	REAC:R-HSA-1280218	Adaptive Immune System	Adaptive Immune System	9	2.565895e-03	3
REAC	REAC:R-HSA-162582	Signal Transduction	Signal Transduction	14	8.999403e-03	3
REAC	REAC:R-HSA-382551	Transport of small molecules	Transport of small molecules	8	1.080036e-02	3
REAC	REAC:R-HSA-5663205	Infectious disease	Infectious disease	9	2.277393e-02	3
REAC	REAC:R-HSA-9824446	Viral Infection Pathways	Viral Infection Pathways	8	3.917973e-02	3

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	10	2.464522e-18	3
GO:BP	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	9	1.816904e-13	3
GO:BP	GO:0140238	presynaptic endocytosis	"A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103]	9	2.828414e-13	3
GO:BP	GO:0036465	synaptic vesicle recycling	"The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane." [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]	9	6.448241e-13	3
GO:BP	GO:0006898	receptor-mediated endocytosis	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]	11	1.835499e-12	3
GO:BP	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	14	2.088627e-12	3
GO:BP	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	14	7.794177e-11	3
GO:BP	GO:0099003	vesicle-mediated transport in synapse	"Any vesicle-mediated transport that occurs in a synapse." [GOC:dos]	10	9.712627e-11	3
GO:BP	GO:0099504	synaptic vesicle cycle	"A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [GOC:aruk, GOC:bc, PMID:15217342]	9	1.494535e-09	3
GO:BP	GO:0098884	postsynaptic neurotransmitter receptor internalization	"A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle." [GOC:dos]	6	1.734888e-09	3
GO:BP	GO:0140239	postsynaptic endocytosis	"A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988]	6	1.734888e-09	3
GO:BP	GO:0099590	neurotransmitter receptor internalization	"A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor." [GOC:dos]	6	4.930825e-09	3
GO:BP	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	15	6.198193e-09	3
GO:BP	GO:0031623	receptor internalization	"A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]	7	1.424346e-07	3
GO:BP	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	18	4.484162e-07	3
GO:BP	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	16	1.209939e-06	3
GO:BP	GO:0070727	cellular macromolecule localization	"Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]	16	1.291291e-06	3
GO:BP	GO:0051649	establishment of localization in cell	"Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	14	2.832699e-06	3
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	"Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos]	6	4.666973e-06	3
GO:BP	GO:0048268	clathrin coat assembly	"The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]	4	6.516113e-06	3
GO:BP	GO:0033036	macromolecule localization	"Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]	16	1.193914e-05	3
GO:BP	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	9	3.369353e-05	3
GO:BP	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	19	4.445343e-05	3
GO:BP	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	11	9.551004e-05	3
GO:BP	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	6	1.454227e-04	3
GO:BP	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	11	1.509187e-04	3
GO:BP	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	12	2.680421e-04	3
GO:BP	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	16	1.127460e-03	3
GO:BP	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	11	2.924345e-03	3
GO:BP	GO:0051234	establishment of localization	"Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]	16	5.505666e-03	3
GO:BP	GO:1903077	negative regulation of protein localization to plasma membrane	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]	3	7.114419e-03	3
GO:BP	GO:1904376	negative regulation of protein localization to cell periphery	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]	3	8.679111e-03	3
GO:BP	GO:1900126	negative regulation of hyaluronan biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]	2	1.071644e-02	3
GO:BP	GO:1905476	negative regulation of protein localization to membrane	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	3	1.591194e-02	3
GO:BP	GO:0030100	regulation of endocytosis	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]	5	2.320140e-02	3
GO:BP	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	11	2.718152e-02	3
GO:BP	GO:0072318	clathrin coat disassembly	"The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system." [PMID:11084334, PMID:11146663, PMID:8524399]	2	4.987700e-02	3
GO:BP	GO:1900125	regulation of hyaluronan biosynthetic process	"Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]	2	4.987700e-02	3

KEGG

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	Endocrine and other factor-regulated calcium reabsorption	9	2.189799e-15	3
KEGG	KEGG:04721	Synaptic vesicle cycle	Synaptic vesicle cycle	8	1.370333e-11	3
KEGG	KEGG:04144	Endocytosis	Endocytosis	8	1.630256e-07	3
KEGG	KEGG:05016	Huntington disease	Huntington disease	8	8.350507e-07	3
KEGG	KEGG:04142	Lysosome	Lysosome	4	4.121281e-03	3
KEGG	KEGG:05100	Bacterial invasion of epithelial cells	Bacterial invasion of epithelial cells	3	1.918764e-02	3

GO:MF

source	term_id	annotation	description	intersection_size	p_value	community
GO:MF	GO:0035615	clathrin adaptor activity	"Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]	6	8.094646e-12	3
GO:MF	GO:0140312	cargo adaptor activity	"Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]	6	2.360719e-11	3
GO:MF	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	6	1.904157e-08	3
GO:MF	GO:0050750	low-density lipoprotein particle receptor binding	"Binding to a low-density lipoprotein receptor." [GOC:ai]	3	1.034071e-03	3
GO:MF	GO:0097718	disordered domain specific binding	"Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698]	3	1.637719e-03	3
GO:MF	GO:0070325	lipoprotein particle receptor binding	"Binding to a lipoprotein particle receptor." [GOC:BHF, GOC:rl]	3	1.818273e-03	3
GO:MF	GO:0032050	clathrin heavy chain binding	"Binding to a clathrin heavy chain." [GOC:mah]	2	2.299654e-02	3
GO:MF	GO:0030674	protein-macromolecule adaptor activity	"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	7	4.462882e-02	3
GO:MF	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	6	4.703994e-02	3

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP2267	Synaptic vesicle pathway	Synaptic vesicle pathway	7	2.203489e-10	3
WP	WP:WP4549	Fragile X syndrome	Fragile X syndrome	8	1.671908e-09	3
WP	WP:WP4159	GABA receptor signaling	GABA receptor signaling	5	2.277150e-07	3
WP	WP:WP437	EGF EGFR signaling	EGF EGFR signaling	6	2.926365e-05	3
WP	WP:WP4829	mBDNF and proBDNF regulation of GABA neurotransmission	mBDNF and proBDNF regulation of GABA neurotransmission	3	5.482078e-03	3

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:247	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex	3	0.000025	3

TF

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M00007	Factor: Elk-1; motif: NAAACMGGAAGTNCVH	Factor: Elk-1; motif: NAAACMGGAAGTNCVH	18	0.010563	3

WashU (Leiden)

View:

WashU (Louvain)

View:

Community 2

GO:CC

source	term_id	annotation	description	intersection_size	p_value	community
GO:CC	GO:0030991	intraciliary transport particle A	"The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]	2	0.000026	2
GO:CC	GO:0030990	intraciliary transport particle	"A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]	2	0.000279	2
GO:CC	GO:0032391	photoreceptor connecting cilium	"The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone." [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680]	2	0.000763	2
GO:CC	GO:0097542	ciliary tip	"Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]	2	0.001050	2
GO:CC	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	2	0.002379	2
GO:CC	GO:0001750	photoreceptor outer segment	"The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins." [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304]	2	0.004245	2
GO:CC	GO:0097733	photoreceptor cell cilium	"A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment." [GOC:cilia, Wikipedia:Photoreceptor_cell#Histology]	2	0.006758	2
GO:CC	GO:0097731	9+0 non-motile cilium	"A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:22118931]	2	0.008171	2
GO:CC	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	2	0.013371	2

CORUM

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:6585	Intraflagellar transport complex A	Intraflagellar transport complex A	2	0.000148	2

GO:BP

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	2	0.000214	2
GO:BP	GO:0021532	neural tube patterning	"The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	2	0.001244	2
GO:BP	GO:0031076	embryonic camera-type eye development	"The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]	2	0.001569	2
GO:BP	GO:0048701	embryonic cranial skeleton morphogenesis	"The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase." [GOC:dsf, GOC:jid, PMID:16049113]	2	0.002229	2
GO:BP	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]	2	0.002771	2
GO:BP	GO:1904888	cranial skeletal system development	"The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227]	2	0.006192	2
GO:BP	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	2	0.006539	2
GO:BP	GO:0048704	embryonic skeletal system morphogenesis	"The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]	2	0.010080	2
GO:BP	GO:0030326	embryonic limb morphogenesis	"The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172]	2	0.018556	2
GO:BP	GO:0035113	embryonic appendage morphogenesis	"The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]	2	0.018556	2
GO:BP	GO:0048706	embryonic skeletal system development	"The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]	2	0.019454	2
GO:BP	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	2	0.026685	2
GO:BP	GO:0035107	appendage morphogenesis	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]	2	0.028123	2
GO:BP	GO:0035108	limb morphogenesis	"The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping." [UBERON:0002101]	2	0.028123	2
GO:BP	GO:0021915	neural tube development	"The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	2	0.029973	2
GO:BP	GO:0010970	transport along microtubule	"The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]	2	0.037119	2
GO:BP	GO:0048736	appendage development	"The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc]	2	0.044113	2
GO:BP	GO:0060173	limb development	"The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378]	2	0.044113	2

WP

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP4532	Intraflagellar transport proteins binding to dynein	Intraflagellar transport proteins binding to dynein	2	0.000399	2
WP	WP:WP5234	Bardet Biedl syndrome	Bardet Biedl syndrome	2	0.004346	2
WP	WP:WP4536	Genes related to primary cilium development based on CRISPR	Genes related to primary cilium development based on CRISPR	2	0.005964	2
WP	WP:WP4803	Ciliopathies	Ciliopathies	2	0.019115	2

REAC

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-5620924	Intraflagellar transport	Intraflagellar transport	2	0.006494	2
REAC	REAC:R-HSA-5610787	Hedgehog 'off' state	Hedgehog 'off' state	2	0.028717	2

HP

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0001407	Hepatic cysts	Hepatic cysts	2	0.009997	2
HP	HP:0001737	Pancreatic cysts	A cyst of the pancreas that possess a lining of mucous epithelium.	2	0.022820	2
HP	HP:0000090	Nephronophthisis	Presence of cysts at the corticomedullary junction of the kidney in combination with tubulointerstitial fibrosis.	2	0.024124	2
HP	HP:0006706	Cystic liver disease	Cystic liver disease	2	0.029702	2
HP	HP:0002612	Congenital hepatic fibrosis	The presence of fibrosis of that part of the liver with congenital onset.	2	0.037490	2
HP	HP:0007401	Macular atrophy	Well-demarcated area(s) of partial or complete depigmentation in the macula, reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss.	2	0.039156	2
HP	HP:0010306	Short thorax	Reduced inferior to superior extent of the thorax.	2	0.044372	2
HP	HP:0003259	Elevated circulating creatinine concentration	An increased amount of creatinine in the blood.	2	0.049914	2

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0018217	peptidyl-aspartic acid phosphorylation	"The phosphorylation of peptidyl-aspartic acid." [GOC:jl]	1	0.049542	20
GO:BP	GO:1903710	spermine transmembrane transport	"The process in which spermine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075]	1	0.049542	20
GO:BP	GO:1990938	peptidyl-aspartic acid autophosphorylation	"The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein." [GOC:bf, GOC:PARL, PMID:26134396]	1	0.049542	20

source	term_id	annotation	description	intersection_size	p_value	community
GO:BP	GO:0075519	microtubule-dependent intracellular transport of viral material	"The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus." [VZ:983]	1	0.049542	28
GO:BP	GO:0075521	microtubule-dependent intracellular transport of viral material towards nucleus	"The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983]	1	0.049542	28
GO:BP	GO:0075606	transport of viral material towards nucleus	"The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane." [GOC:bf, GOC:jl, VZ:990]	1	0.049542	28

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:04720	Long-term potentiation	Long-term potentiation	2	0.009078	3
KEGG	KEGG:05214	Glioma	Glioma	2	0.011387	3
KEGG	KEGG:04211	Longevity regulating pathway	Longevity regulating pathway	2	0.016051	3
KEGG	KEGG:04725	Cholinergic synapse	Cholinergic synapse	2	0.025889	3
KEGG	KEGG:04722	Neurotrophin signaling pathway	Neurotrophin signaling pathway	2	0.028230	3
KEGG	KEGG:04371	Apelin signaling pathway	Apelin signaling pathway	2	0.038597	3
KEGG	KEGG:04921	Oxytocin signaling pathway	Oxytocin signaling pathway	2	0.048041	3

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0011321	Left unilambdoid synostosis	Premature synostosis of only the left lambdoid suture.	1	0.049962	3
HP	HP:0100955	Giant cell granuloma of mandible	Giant cell granuloma of mandible	1	0.049962	3

source	term_id	annotation	description	intersection_size	p_value	community
WP	WP:WP5124	Alzheimer 39 s disease	Alzheimer 39 s disease	3	0.008566	4
WP	WP:WP2059	Alzheimer 39 s disease and miRNA effects	Alzheimer 39 s disease and miRNA effects	3	0.009067	4
WP	WP:WP3286	Copper homeostasis	Copper homeostasis	2	0.016747	4
WP	WP:WP661	Glucose homeostasis	Glucose homeostasis	1	0.038601	4

source	term_id	annotation	description	intersection_size	p_value	community
KEGG	KEGG:05010	Alzheimer disease	Alzheimer disease	3	0.018810	4
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	Pathways of neurodegeneration - multiple diseases	3	0.035689	4

source	term_id	annotation	description	intersection_size	p_value	community
CORUM	CORUM:5830	DJ-1-SNCA complex, high molecular weight complex	DJ-1-SNCA complex, high molecular weight complex	1	0.049932	9
CORUM	CORUM:7241	SNCA-TUBB3 complex	SNCA-TUBB3 complex	1	0.049932	9

source	term_id	annotation	description	intersection_size	p_value	community
HP	HP:0034552	Abnormal peroxisomal morphology	Structural anomaly of peroxisomes, which are small, membrane-enclosed metabolic organelles with roles in the metabolism of complex lipids and reactive ionic species.	1	0.049962	16
HP	HP:0034553	Absence of peroxisomes	Lack of observable peroxisomes. This feature can be observed by immunohistochemical staining of cultured cells (such as fibroblasts) or by electronmicroscopy.	1	0.049962	16

source	term_id	annotation	description	intersection_size	p_value	community
TF	TF:M11463_1	Factor: nerf; motif: NACCCGGAAGTR; match class: 1	Factor: nerf; motif: NACCCGGAAGTR; match class: 1	1	0.012443	28
TF	TF:M03968_1	Factor: ELF4; motif: AACCCGGAAGTR; match class: 1	Factor: ELF4; motif: AACCCGGAAGTR; match class: 1	1	0.012443	28
TF	TF:M05442	Factor: NOR1; motif: TGTTTAGATCAN	Factor: NOR1; motif: TGTTTAGATCAN	1	0.049771	28

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:hsa-mir-598-5p	hsa-mir-598-5p	hsa-mir-598-5p	1	0.022595	28
MIRNA	MIRNA:hsa-mir-8088	hsa-mir-8088	hsa-mir-8088	1	0.024855	28

source	term_id	annotation	description	intersection_size	p_value	community
MIRNA	MIRNA:mir-let7d-5p	mir-let7d-5p	mir-let7d-5p	1	0.002260	9
MIRNA	MIRNA:hsa-mir-487b-3p	hsa-mir-487b-3p	hsa-mir-487b-3p	1	0.036152	9

source	term_id	annotation	description	intersection_size	p_value	community
REAC	REAC:R-HSA-9649913	RAS GTPase cycle mutants	RAS GTPase cycle mutants	1	0.037449	9
REAC	REAC:R-HSA-9753510	Signaling by RAS GAP mutants	Signaling by RAS GAP mutants	1	0.037449	9
REAC	REAC:R-HSA-9753512	Signaling by RAS GTPase mutants	Signaling by RAS GTPase mutants	1	0.037449	9

biogrid+hippie (Leiden)

Community 0

REAC

WP

GO:CC

KEGG

GO:MF

GO:BP

CORUM

MIRNA

HPA

HP

Community 1

GO:CC

GO:BP

REAC

GO:MF

KEGG

WP

CORUM

MIRNA

HPA

Community 2

CORUM

GO:CC

Community 3

MIRNA

GO:CC

KEGG

GO:MF

GO:BP

Community 4

KEGG

GO:CC

REAC

CORUM

WP

GO:MF

TF

HP

Community 5

GO:BP

GO:MF

REAC

KEGG

Community 8

WP

CORUM

GO:CC

Community 9

WP

Community 11

MIRNA

CORUM

Community 12

WP

GO:MF

Community 13

WP

GO:CC

KEGG

Community 14

GO:BP

CORUM

Community 15

HPA

Community 18

HP

Community 20

GO:BP

GO:MF

Community 23

MIRNA

Community 28

GO:BP

biogrid+hippie (Louvain)

Community 0

GO:BP

GO:CC

Community 1